携氧液对大鼠高血压脑出血脑保护的实验研究  

Protective effect of oxygen carrying liquid to brain tissue after hypertensive intracerebral hemorrhage in rats

作　　者：刘宏毅[1] 李明[2] 邹元杰[1] 张岩松[1] 常义[1] 肖红[1] 

机构地区：[1]南京医科大学附属脑科医院,210029 [2]南京大学医学院

出　　处：《临床神经病学杂志》2000年第6期335-338,共4页Journal of Clinical Neurology

摘　　要：目的　研究携氧液对大鼠高血压脑出血脑组织的保护作用。方法　通过立体定向手术对大鼠脑尾状核用胶原酶加肝素联合注射诱导大鼠出血模型 ,观察各组大鼠脑含水量、组织形态学、脑血流及生化指标的变化。结果　 B组 (非携氧液组 )患侧组织形态学及细胞器损伤明显较 A组 (携氧液组 )严重 ;B组脑含水量 (80 .5 5± 0 .80 % )高于 A组 (77.94± 1.16 % )、B组髓鞘碱性蛋白 (MBP)和神经元特异性烯醇化酶 (NSE)分别为 0 .87± 0 .44 ng/ml、1.74± 0 .6 8ng/ml,A组为 0 .5 4± 0 .19ng/ml、1.19± 0 .49ng/m l,两组具有显著性差异 (均 P <0 .0 1)。Objective To study the protective effect of oxygen carrying liquid to brain tissue after hypertensive intracerebral hemorrhage in rats.Methods Collagenase and heparin were injected into the caudate nucleus of rats by stereotactic operation to induce a hemorrhage model,we observed the water content of brain,the morphology of the brain,the change of cerebral blood flow (CBF) and biochemical markers in each group.Results Group B without oxygen carrying liquid had more serious injury than group A with oxygen carrying liquid.Water content of brain tissue in group B (80.55±0.80%) was higher than group A (77.94±1 16%),group B had higher MBP levels(0.87±0.44 ng/ml) than group A (0.54±0.19 ng/ml), group B had higher NSE levels (1.74±0.68 ng/ml) than group A (1.19±0 49 ng/ml),There was remarkable difference in the two groups.Conclusion The oxygen carrying liquid had fine protective effect to the brain tissue around the hematoma after hypertensive intracerebral hemorrhage.

关 键 词：携氧液 脑出血 实验 高血压 治疗 

分 类 号：R743.34[医药卫生—神经病学与精神病学]