直肠癌组织中TP表达及其临床意义  

Clinical significance of Thymidine Phosphorylase(TP) Expression in Rectal Cancer

作　　者：胡从兵[1] 谢建平[1] 邓黎[1] 

机构地区：[1]长江大学临床医学院 荆州市第一人民医院普外科,湖北荆州434000

出　　处：《长江大学学报（自科版）（下旬）》2013年第12期7-9,5,共3页Journal of Yangtze University

摘　　要：目的:观察直肠癌组织中胸苷磷酸化酶(TP)表达阳性情况,探讨其表达与临床病理参数之间的关系。方法:使用免疫组化方法检测直肠癌124例患者癌组织中TP表达:癌组织中染色细胞≥5%则为TP阳性。结果:直肠癌组织中TP阳性率为50%,TP表达与肿瘤浸润深度、解剖学分期有关联。结论:胸苷磷酸化酶在直肠癌组织及转移组织中明显高于正常组织,能诱导肿瘤组织中血管生长。TP表达阳性可能提示预后不良。Objective: To evaluate Thymidine phosphorylase(TP) expression in rectal cancer tissues and find its relationship with clinicopathological parameters. Methods: Samples studied consisted of one hundred and twenty-four patients with rectal cancer. Immunohistochemical staining for TP was done and the tumor was considered positive when more than 5% of cells were stained. Results: The positive rate of TP expression in rectal carcinoma was fifty percent and TP expression was correlated with depth of invasion and stage. Conclusion: Thymidine phosphorylase has an angiogenic effect and is higher in rectal cancer tissues than in normal tissues beside the tumor. TP expression indicates a bad prognosis in rectal carcinoma.

关 键 词：直肠癌 胸苷磷酸化酶(TP) 免疫组化 临床病理特征 

分 类 号：R735.37[医药卫生—肿瘤]