精神分裂症患者氯丙嗪治疗前后血小板聚集功能观察  

Observation of platelet aggregating function berore and after treatment of chlorpromazine in schizophrenia

作　　者：张秀明[1] 沈琪琳[1] 祁富生[1] 张晨光 

机构地区：[1]河南省精神病医院,453002

出　　处：《上海精神医学》2000年第4期204-205,共2页Shanghai Archives of Psychiatry

摘　　要：目的 探讨精神分裂症患者血小板聚集功能及氯丙嗪治疗对血小板聚集功能的影响。方法 对33例首次住院的男性精神分裂症患者氯丙嗪治疗前后进行BPRS评定及肾上腺素致聚下的血小板聚集功能检测,并与55名正常对照相比较。结果 精神分裂症患者血小板1分钟聚集率(PAR1)、5分钟聚集率(PAR5)显著高于对照组(P<0.05,P<0.01);用氯丙嗪治疗1个月后,患者临床症状缓解,BPRS评定分值下降(P<0.01),血小板聚集功能PAR1无显著性改变(P>0.05),PAR5明显升高(P<0.01)。结论 精神分裂症患者血小板聚集功能增强;氯丙嗪治疗可导致血小板的激活状态。Objectives: To study the platelet aggregating function of schizophrenia and the effect of chlorpromazine on platelet aggregating function. Method: The platelet aggregating function aggregated by adrenaline was determined in pre- and post-treatment of chlorpromazine in 33 first-onset male schizophrenics, and compared with 55 normals. Results: The PAR1 and PAR5 of schizophrenia were significantly higher than that of normals (p<0. 05,P<0. 01); After one month treatment of chlorpromazine, PAR1 had no significant change(p>0. 05),and PAR5 was significantly elevated (p<0. 01). Conclusion: The platelet aggregating function was strengthened in schizophrenia and the chlorpromazine treatment might produce activated state of platelet function.

关 键 词：精神分裂症 氯丙嗪 血小板聚集 治疗 

分 类 号：R749.3[医药卫生—神经病学与精神病学]