氟西汀合并抗精神病药物治疗精神分裂症阴性症状的研究  

Trial of fluoxetine added to neuroleptics for chronic schizophrenic patients.

作　　者：王定省[1] 高哲石[1] 沈阿珍[1] 何怡发[1] 吴国君[1] 谢帆[1] 

机构地区：[1]上海市精神卫生中心,200030

出　　处：《上海精神医学》2000年第4期208-210,218,共4页Shanghai Archives of Psychiatry

摘　　要：目的 探讨抗精神病药加用氟西汀治疗精神分裂症阴性症状的临床疗效。方法 对原用抗精神病药治疗的以阴性症状为主的46例慢性精神分裂症病人,加用氟西汀,用SANS,SAPS和TESS评定加药前后精神症状和不良反应,用配对t检验进行自身对照分析。结果 加氟西汀后,SANS和SAPS总分明显下降(P<0.05),阴性症状严重者(SANS总分≥60分)减分明显。结论 阴性症状严重的慢性精神分裂症病人,抗精神病药物加氟西汀治疗,有效机率增加。Objectives: To explore the effectiveness of fluoxetine addition to neuroleptics in the treatment of chronic schizophrenic patients. Method: Fluoxetine was added to neuroleptic treatment in 46 cases of schizophrenic patients with prominent negative symptoms, and SANS, SAPS and TESS were used to evaluate, the changes of psychiatric symptoms and side effects. Results; After fluoxetine augmentation, the total scores of SANS and SAPS were significantly decreased (P<0. 05), especially in those who had shown negative symptoms prominently before the trial. Conclusion: Fluoxetine addition was effective in the chronic schizophrenics with serious negative symptoms.

关 键 词：氟西汀 慢性精神分裂症 阴性症状 治疗 

分 类 号：R749.3[医药卫生—神经病学与精神病学]