海洛因中毒性脑病的临床与磁共振成像  

Clinical manifestation and MRI feature on toxic encephalopathy after inhaling and injecting heroin

作　　者：蔡兴秋[1] 张贞浏[1] 赵翕平[1] 霍晓丽[1] 

机构地区：[1]南京医科大学附属脑科医院神经科,210029

出　　处：《中华神经科杂志》2000年第6期342-345,I028,共5页Chinese Journal of Neurology

摘　　要：目的　研究海洛因中毒性脑病的临床表现及磁共振成像 (MRI)特征。方法　对 4例海洛因中毒性脑病患者进行临床及MRI观察。结果　 4例均为男性 ,均有明确的吸毒史 (吸毒时间 4个月至 7年 ) ,除具有反应迟钝、智力障碍等常见的中毒性脑病特征外 ,尚有特殊的语言及肌张力障碍 ;头颅MRI显示双侧对称性大脑半球、内囊后肢、胼胝体、内侧丘系、小脑半球齿状核的广泛脱髓鞘改变。经皮质激素等治疗后 1例在病后 11个月时临床症状几乎消失 ,2例在治疗 3个月后病情减轻 ,1例吸毒长达 7年者 ,病情迅速恶化 ,于病后第 5 5天死亡。结论　认识海洛因中毒性脑病的临床表现及MRI特征 ,使本病患者得到及时的诊治。Objective To study the clinical manifestation and MRI feature on toxic encephalopathy after inhaling and injecting heroin. Methods 4 patients with toxic encephalopathy induced by inhaling, injecting heroin were observed with clinical and MRI. Results The 4 patients were male, they all had definite addiction histories (the time of addiction for 4 months to 7 years), there were special language and retropulsive dystonia besides there were common characteristics of toxic encephalopathy: reaction retardation, disturbance of intelligence, MRI showed the change of generalized demyelination in bilateral symmetrical cerebral hemisphere, posterior limbs of internal capsule, corpus callosum, medial lemniscus, cerebellum hemisphere dentate nucleus. The clinical symptom of 1 patient treated by adrenocortical steroid disappeared nearly 11 months after the onset of disease, 2 patients’ condition was remitted 3 months after treatment, 1 patient with 7 years inhaling history died the 55th day after the deterioration of disease. Conclusion Clinical manifestation and MRI on toxic encephalopathy after inhaling and injecting heroin were known, so we could diagnose the patients of the disease in time.

关 键 词：海洛因中毒 脑疾病 磁共振成像 临床表现 

分 类 号：R749.6[医药卫生—神经病学与精神病学]