大肠癌癌旁移行粘膜p^(21)表达的意义  

CLINICAL STUDY OF RAS P^（21）EXPRESSION IN TRANSITIONAL MUCOSA ADJACENT TO COLORECTAL CANCER

作　　者：徐亮[1] 肖惠[2] 卢光宇 

机构地区：[1]泸州医学院附属医院胃肠外科,646000 [2]泸州医学院学报编辑部 [3]中山医科大学,646000

出　　处：《泸州医学院学报》1999年第4期288-289,共2页Journal of Luzhou Medical College

摘　　要：探讨大肠癌癌旁移行粘膜p21表达的意义。方法：应用流式细胞术和细胞免疫荧光染色技术，对35例结直肠癌和癌旁移行粘膜的p21表达进行定量研究。结果：结直肠癌和癌旁移行粘膜的p21表达阳性率分别为65．7％和60.0％，但癌组织的p21表达量明显高于癌旁移行粘膜；p21表达阳性的移行粘膜全部分布于p21表达阳性的癌组织中。结论：癌旁移行粘膜属癌前病变，外科手术时应切除足够长度的p21表达阳性的移行粘膜，以防止术后局部复发癌。To Study ras P21 expression in tran sitional mucosa adjacent to colorectal cancer. Methods:The oncogne ras P21 expression in 35 cases of colorectal cancer and their transitional mucoas were analysed quantitativelywith flow cytometry and cyto- immunofluorescence staining technique. Results: The posititve rate of ras P21 expessionwere 65. 7% and 60. 0% in colorectal carcinomas and fransitional mucosa respectively. Ras P21 expression was higher incolorectal adenocarcinomas than that of the transitional mucosa. The transitional mucosa that ras P21 expression were posi-tive were distributed in carcinomas of ras P21 positive expression. Conclusion: Transitional mucosa adjacent to cancer werepremalignant lesions, they should be thoroughly reasetsd during the operation in order to prevent local recurrence of can-cer.

关 键 词：大肠癌 癌旁移行粘膜 P^21 基因表达 

分 类 号：R735.34[医药卫生—肿瘤]