中国人群5,10-亚甲基四氢叶酸还原酶基因C677T多态性与非综合征性唇腭裂关系的Meta分析  

Relationship between 5,10-methylenetrahydrofolate Reductase C677T Polymorphism and Non-syndrome Cleft Lip and Palate in China: A Meta-analysis

作　　者：朱博[1,2] 王达[1] 杨博逸[1] 刘宇岩[1] 李永芳[1] 孙贵范[1] 

机构地区：[1]中国医科大学公共卫生学院劳动卫生教研室,辽宁省沈阳市110001 [2]辽宁省安全科学研究院

出　　处：《中国全科医学》2013年第32期3825-3827,共3页Chinese General Practice

基　　金：国家自然科学基金资助项目(81072243)

摘　　要：目的评价5,10-亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性与中国人群非综合征性唇腭裂(NSCL/P)的关系。方法计算机检索中国生物医学文献数据库、中国学术期刊全文数据库、万方中文科技期刊全文数据库、重庆维普中文科技期刊全文数据库等,检索时间范围2000年1月—2012年12月。选择MTHFR基因C677T多态性与NSCL/P的病例对照研究,评价纳入研究质量,并采用RevMan 5.0统计学软件进行定量分析。结果共纳入7个病例对照研究。Meta分析结果表明,携带T等位基因人群患有NSCL/P的危险性高于携带C等位基因人群〔OR=1.48,95%CI(1.06,2.07)〕。携带TT基因型人群NSCL/P发病危险性高于非携带TT基因型人群〔OR=1.35,95%CI(1.01,1.80)〕。携带CT和TT基因型人群NSCL/P发病危险性高于携带CC基因型人群〔OR=2.40,95%CI(1.20,4.77)〕。结论 MTHFR基因C677T多态性与我国人群NSCL/P的易患性密切相关。Objective To evaluate the relationship between 5, 10 - reductase （MTHFR） C677T gene polymorphism and non -syndrome cleft lip and palate in China. Methods CBM, CNKI, Wanfang and VIP data- bases from January 2000 to December 2012 were searched by computer. Case - control studies of 5, 10 - methylenetrahydrofolate reductase C677T polymorphism and non - syndrome cleft lip and palate were selected. The quality of included studies was as- sessed and the data were quantitatively analyzed by RevMan 5.0 software. Results Totally seven case - control studies were in- volved. Meta - analysis showed that the risk of cleft lip and palate in the group of carrying the T allele was higher than that of car- rying the C allele groups ~ OR = 1.48, 95 % CI （ 1.06, 2. 07） ]. The risk in the group of the 13＂ genotype was higher than the control group of the non -TY genotype [ OR = 1.35, 95% CI （ 1.01, 1.80） 1. The risk in the case group of the CT and TI＂ genotypes was higher than control group of CC genotype [ OR = 2. 40, 95% C1 （ 1.20, 4. 77 ） ]. Conclusion 5, 10 - methyl- enetrahydrofolate reductasc C677T polymorphism is significantly associated with susceptibility of non - syndrome cleft lip and pal- ate in China

关 键 词：5 10-亚甲基四氢叶酸还原酶 唇裂 腭裂 基因 多态性 单核苷酸 META分析 

分 类 号：R782.21[医药卫生—口腔医学]