凋亡相关基因与食管鳞状细胞癌放射敏感性相关关系的研究  

Study on relationship between apoptosis-related genes and radiosensitivity of esophageal squamous cell carcinoma

作　　者：李惠翔[1] 王尧河[1] 石永刚[2] 高冬玲[1] 张云汉[1] 

机构地区：[1]河南医科大学附属一院病理科,郑州450052 [2]河南医科大学附属一院放疗科,郑州450052

出　　处：《中华放射医学与防护杂志》2000年第6期411-413,共3页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的　探讨凋亡相关基因bcl 2 ,c myc ,p5 3与食管鳞癌放疗敏感性的关系。 方法　采用免疫组化LSAB方法检测食管癌活检组织中bcl 2 ,c myc,p5 3基因表达水平。病人接受放射治疗 ,观察疗效 ,分析基因表达与放射敏感性的关系。结果　bcl 2蛋白表达阳性者放射敏感性明显低于表达阴性者 ,p5 3蛋白表达阳性者略差于阴性者 ;c myc基因表达与放射敏感性无关。 结论　bcl 2 ,c myc,p5 3等凋亡相关基因表达产物的检测及综合分析有助于食管鳞癌放疗疗效的预测。Objective\ To observing the relationship between apoptosis\|ralated genes bcl\|2,c\|myc,p53 and the radiosensitivity of esophageel squamous cell carcinoma. Methods\ The expression levels of bcl\|2,c\|myc and p53 genes in 57 biopsy samples from patients of esophageal squamous cell carcinoma were detected with the LSAB immunohistochemistry method.All the patients were treated with radiotherapy.The radiotherapeutic effect in these patients was observed and the relation between gene expression and radiosensitivity was analyzed. Results\ Compared with the bcl\|2\|negative group,the radiosensitivity of bcl\|2\|positive one was lower(P<0.01).The radiosensitivity of p53\|positive group was slightly lower than that of the p53\|negative one (P<0 05).The c\|myc protein expression was not related to radiosensitivity. Conclusion\ Detection and comprehensive analysis of bcl\|2,c\|myc and p53 protein expressions are useful in forecasting the radiotherapeutic effect on squamous cell carcinoma of esophagus.\;

关 键 词：食管鳞状细胞癌 凋亡相关基因 食管癌 放射疗法 

分 类 号：R735.1[医药卫生—肿瘤] R730.55[医药卫生—临床医学]