急性期脑梗死患者血清fibulin-5水平及其与病情的关系  

The Serum Level of Fibulin- 5 in Patients with Acute Cerebral Infarction and Its Relationship with Severity of Illness

作　　者：赵辉[1] 徐广会[1] 秦新月[1] 

机构地区：[1]重庆医科大学附属第一医院神经内科,重庆市400016

出　　处：《中国全科医学》2013年第33期3920-3922,共3页Chinese General Practice

基　　金：国家自然科学基金面上项目(81271307)

摘　　要：目的探讨急性期脑梗死患者血清fibulin-5水平变化及其与病情的关系。方法选取2012年4—11月我科收治的急性期脑梗死患者156例(观察组),发病时间均<72 h。另选取50例性别、年龄与观察组相匹配的体检健康者作为对照组。应用酶联免疫吸附双抗体夹心法检测所有受检者血清fibulin-5水平,同时采用美国国立卫生研究院脑卒中量表(NIHSS)对观察组患者进行神经功能缺损评分,然后分析观察组不同英国牛津郡社区脑卒中项目(OCSP)分型、梗死面积、梗死部位者血清fibulin-5水平间的差异,并探讨血清fibulin-5水平与NIHSS评分的关系。结果观察组患者血清fibulin-5水平高于对照组〔(118.7±51.6)μg/L与(40.1±12.2)μg/L,t=-11.56,P<0.01〕。不同OCSP分型、梗死面积组患者血清fibulin-5水平间差异有统计学意义(F值分别为23.48和208.32;P<0.01);其中完全前循环梗死〔(182.1±53.1)μg/L〕>后循环梗死〔(135.4±48.7)μg/L〕>部分前循环梗死〔(104.9±21.6)μg/L〕>脑腔隙性梗死〔(69.3±7.9)μg/L,均P<0.01〕;大面积梗死〔(198.7±26.0)μg/L〕>小面积梗死〔(104.0±55.8)μg/L〕>腔隙性梗死〔(68.0±7.8)μg/L,均P<0.01〕;而不同梗死部位的患者血清fibulin-5水平间差异无统计学意义(P>0.05)。急性期脑梗死患者血清fibulin-5水平与NIHSS评分呈正相关(r=0.792,P<0.01)。结论急性期脑梗死患者血清fibulin-5水平较健康者升高,且随着脑梗死病灶的增大而升高,但与脑梗死病变部位无相关性。故血清fibulin-5水平检测可能对评估患者的病情有一定的指导意义。Objective To investigate the serum level of serum fibulin - 5 in patients with acute cerebral infarction and its relationship with severity of illness. Methods 156 patients with acute cerebral infarction （ time of onset 〈 72 h） who admitted to our department from April to November 2012, were selected as the observation group, and 50 healthy people were selected as control group, the gender and age of control group were similar to those of observation group. The serum levels of fibulin - 5 of all cases were detected by ELISA, neurologic impairment scores in observation group were evaluated using NIHSS, the relationships between the serum levels of fibulin - 5 and OCSP subtype, infarct size, infarct location and NIHSS score. Results The serum level of fibulin-5 in observation group [ （118.7 ＋51.6） lxg/L3 was significantly higher than that in control group ~ （40. 1 ＋ 12. 2） I^g/L, t = - 11.56, P 〈 0. 01 ~ . The serum level of fibulin - 5 in observation group changed with OCSP subtype and infarct size, the differences were statistically significant （ F values were 23.48 and 208.32, separately; P 〈 0. O1 ） ; The serum levels of fibulin - 5 in patients with total anterior circulation infarction, posterior circulation infarction, partial anterior circulation infarction and lacunar infarction decreased progressively [ （ 182. 1 ＋ 53.1 ） p^g/L, （ 135.4 ＋ 48.7 ） Ixg/L, （ 104. 9 -＋ 21.6 ） ixg/L, （69.3 ＋7.9） Ixg/L; all P 〈0. 013 ; There was no significant difference in the serum levels of fibulin -5 among patients with different infarct locations （P 〉 0. 05 ） . The serum level of fibulin - 5 was positively correlated with NIHSS score among pa- tients with acute cerebral infarction （ r = 0. 792, P 〈 0.01 ） . Conclusion The level of fibulin - 5 in patients with acute cerebral infarction was significantly higher than that in healthy people, the level of fibulin - 5 in patients with acute cerebral infarction in- creased with the increased infarct size. However, there

关 键 词：脑梗死 FIBULIN-5 脑血管循环 

分 类 号：R743.33[医药卫生—神经病学与精神病学]