阿加曲班治疗短暂性脑缺血发作的临床疗效观察  

Clinical Efficacy of Argatroban in the Treatment of Transient Ischemic Attack

作　　者：张艳秋[1] 邵义泽[1] 

机构地区：[1]天津市南开医院脑系科,300100

出　　处：《实用心脑肺血管病杂志》2013年第12期34-35,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的观察阿加曲班治疗短暂性脑缺血发作(TIA)的临床疗效。方法选取我院2009年8月—2011年10月住院治疗的TIA患者64例,将其随机分为治疗组和对照组。在常规治疗基础上,对照组加用氯吡格雷抗血小板治疗;治疗组加用阿加曲班抗凝治疗7 d,后给予氯吡格雷抗血小板治疗7 d,疗程均为14 d。结果治疗组总有效率为93.8%(20/32),高于对照组的65.6%(21/32)(P<0.05);两组患者在治疗过程中均未出现明显不良反应。结论阿加曲班治疗TIA疗效显著,且安全可行。Objective To explore the clinical efficacy of argatroban in the treatment of transient isehemie attack （TIA）. Methods 64 patients with TIA admitted to our hospital from August 2009 to October 2011 were chosen, and they were randomly divided into treatment group and control group. Based on the routine therapy, patients in the control group were given clopidogrel to inhibit platelet aggregation, patients in the treatment group given argatroban for 7 days, elopidogrel for the next 7 days. Both groups treated for 14 days. Results The total effective rate of treatment group was 93.8% （20/32）, higher than that of control group of 65.6% （21/32） （P 〈0. 05） ; There was no obvious adverse reactions in the two groups during treatment. Conclusion Argatroban is effective in the treatment of TIA, safe and feasible.

关 键 词：阿加曲班 脑缺血发作 短暂性 治疗结果 

分 类 号：R743.31[医药卫生—神经病学与精神病学]