GC顶空进样测定注射用葛根素中残留溶剂乙醇  

Determination of residual solvent ethanol in Puerarin Injection by GC Headspace Sampler

作　　者：林升[1] 

机构地区：[1]福建医科大学附属第一医院药剂科,福州350004

出　　处：《海峡药学》2013年第11期70-71,共2页Strait Pharmaceutical Journal

摘　　要：目的建立GC法检查葛根素中残留溶剂乙醇的方法。方法采用GC法测定,色谱条件为:采用DB-624毛细管柱为色谱柱(30m×0.32mm,0.25μm),柱温40℃保持10min,20℃/min升至180℃;检测器为氢火焰离子化检测器(FID),检测器温度为300℃;进样口温度为220℃。结果乙醇的检测限为9.3508μg·mL-1。结论本法简便、准确、灵敏度高,适用于葛根素中乙醇的测定。OBJECTIVE To establish a GC method to determine residual solvent ethanol in Puerarin Injection. METHODS DB-624 capillary column （ 30m × 0. 32mm, 0. 25 μm） was used, column temperature was 40℃ keep 10min,20℃/min to 180℃ ;the temperature of FID detector was 300℃ ;the temperature of Injection Port was 220℃. RESULTS Limits of detection was relatively 9. 3508μg . mL^-1. CONCLUSION The method is convenient, accurate and has high sensitive,which can be used to detect residual solvent ethanol in Puerarin Injection.

关 键 词：葛根素 溶剂残留 乙醇 GC 

分 类 号：R927.2[医药卫生—药学]