脑脉舒康胶囊对小鼠急性脑缺血模型的影响  

Effects of Naomai Shukang Capsule on Mice Acute Cerebral Ischemia Model

作　　者：白明[1] 刘丹丹[1] 王灿[1] 耿新生[1] 苗明三[1] 

机构地区：[1]河南中医学院,郑州450003

出　　处：《中国实验方剂学杂志》2013年第24期255-257,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河南省重大科技攻关项目(0322031000);国家"重大新药创制"科技重大专项项目(2009ZX09103-324)

摘　　要：目的:探讨脑脉舒康胶囊(NMSKC)对小鼠脑缺血模型的影响。方法:采用昆明种小鼠,分为脑脉舒康胶囊组(4.0,2.0,1.0 g·kg-1)、模型对照组、阳性药(华佗再造丸2.67 g·kg-1,尼莫地平0.02 g·kg-1)对照组,各组连续灌胃9 d,于第10天给药1 h后,快速断头法制备小鼠急性全脑缺血模型,记录小鼠的喘息次数和喘息维持时间,取小鼠脑组织测定丙二醛(MDA)、乳酸(LD)的含量和超氧化物歧化酶(SOD)、乳酸脱氢酶(LDH)的活力。结果:脑脉舒康胶囊可以明显增加断头小鼠的呼吸次数及延长呼吸持续时间,并可降低MDA和LD含量,提高SOD和LDH的活力。结论:脑脉舒康胶囊对小鼠脑缺血机体有一定的保护作用。Objective： To investigate the effects of Naomai Shukang capsule（NMSKC）on mice acute cerebral ischemia model. Method： Kunming mice were divided into six groups：Naomia Shukang capsule groups（4.0,2.0,1.0 g·kg-1）,model control group,positive medicine control groups（Huatuo Zaizao pill 2.67 g·kg-1,Nimodipine 0.02 g·kg-1）.The mice acute cerebral ischemia model was established by rapid head-breaking method,and recorded the respiratory frequency and duration, the brain tissue was collected foe measurement of the contents of lactic acid （LD）,lactic dehydrogenase （LDH）, malondiadehyde （MDA） and superoxide dismutase （SOD）activity. Result： Naomai Shukang capsule could significantly increase respiratory rate and prolong respiratory and reduce the contents of LA and MDA, and increase the activities of LDH and SOD in brain tissue. Conclusion： Naomai Shukang capsule has protective effects on acute cerebral ischemia injury in mice.

关 键 词：脑脉舒康胶囊 急性脑缺血模型 丙二醛 乳酸 超氧化物歧化酶 乳酸脱氢酶 

分 类 号：R285.5[医药卫生—中药学]