MDM2mRNA过度表达与儿童急性淋巴细胞白血病免疫分型、FAB分型及高白细胞的关系  

Relationship of oncogene MDM2 over-expression with immunophenotype, FAB classification and high leucocyte count in children with acute lymphoblastic leukemia

作　　者：蒋莎义[1] 陈力军[1] 高飞[1] 刘廷亮[1] 李桂梅[1] 尹洪臣[1] 

机构地区：[1]山东省立医院儿科,250021

出　　处：《临床儿科杂志》2000年第6期331-332,354,共3页Journal of Clinical Pediatrics

基　　金：山东省卫生厅青年基金 1999CAZOBB3

摘　　要：为了研究癌基因MDM2mRNA过度表达与儿童急性淋巴细胞白血病(ALL)的免疫分型、FAB分型及临床高白细胞性的关系,用RT-PCR法检测了32例急性淋巴细胞白血病患儿外周血单个核细胞内MDM2mRNA表达水平,并分析MDM2mRNA过度表达与不同型别的关系。高白细胞性白血病(HAL)MDM2表达明显高于非高白细胞性白血病(NHAL)组(P=0.0099);T淋巴细胞白血病(T-ALL)与非T淋巴细胞白血病(Non-T-ALL)间(P=0.7345),L_1型急性淋巴细胞白血病与L_2型间(P=0.8923)的MDM2mRNA表达水平无差异。提示MDM2mRNA过度表达与儿童急性淋巴细胞白血病的高白细胞性相关。In order to study the relationship of the expression level of oncogene MDM2 with immunophenotype, FAB classification and high leucocyte count in children with acute lymphoblastic leukemia (ALL), MDM2mRNA expression in individual peripheral leucocyte was assessed using RT-PCR technique in 32 children with ALL. These cases were clinically divided into several sub-groups including T-ALL and non-T-All,L1 and L2 as well as hyperleucocytic ALL(HALL) and non-hy-perleucocytic ALL(NHALL). As a result, although no significant difference in the level MDM2 expression could be detected between T-ALL and non-T-ALL sub-groups(P = 0. 7345) as well as L1 and L2 sub-groups (P=0. 8923)MDM2 over-expression was dramatically seen in HALL as compared to that of NHALL(P = 0. 0099). These findings suggested that oncogene MDM2 over-expression might be closely associated with high leucocyte count (HALL),but not with the immunophenotype and FAB classification in childhood ALL.

关 键 词：MDM2 mRNA 急性白血病 ALL 免疫分型 FAB分型 

分 类 号：R733.71[医药卫生—肿瘤] R730.23[医药卫生—临床医学]