放射治疗在隆突性皮肤纤维肉瘤中的地位  

The role of radiotherapy in the treatment of dermatofibrosarcoma protuberans

作　　者：郑明章[1] 陈志坚[1] 林志雄[1] 李德锐[1] 

机构地区：[1]汕头大学医学院肿瘤医院放射治疗科,515031

出　　处：《中华放射肿瘤学杂志》2000年第4期241-242,共2页Chinese Journal of Radiation Oncology

摘　　要：目的　研究放射治疗在隆突性皮肤纤维肉瘤 (DFSP)中的价值。方法　回顾性分析1995年以来收治的 18例DFSP患者 ,所有病例经组织病理学确诊。手术 +放射治疗 15例 ,术后放射治疗剂量多数在 5 0～ 6 0Gy ,其中 1例 37.5Gy后拒绝继续放射治疗 ,1例因肿瘤残存 ,照射 70Gy。单纯放射治疗 2例 ,剂量分别为 5 2Gy和 5 0Gy。单纯手术 1例。结果　 9例既往发生过 31次复发 ,7/ 9的第 1次复发发生在 6个月内。本次治疗后 ,随访 0 .5～ 5 .0年 ,中位随访时间 2 6个月。无瘤生存 16例 ,失败 2例 ,其中 1例单纯放射治疗 5 2Gy者 ,2 1个月死于局部未控 ,1例单纯手术者 ,4个月后局部复发。手术 +放射治疗的 15例全部达到局部控制。Objective To evaluate the role of radiotherapy in the management of dermatofibrosarcoma protuberans. Methods Between 1995 and 1999, 18 patients with pathologically confirmed dermatofibrosarcoma protuberans were retrospectively analyzed. Nine patients were referred to our hospital for primary treatment and the remaining 9 patients came with recurrent disease. Fifteen of 18 patients received surgery followed by radiotherapy. Among them, 14 patients underwent complete resection and 1 partial resection. Majority of patients received 50～60 ?Gy. One patient received 37.5 ?Gy because he refrained from further treatment. Two patients received 52 ?Gy and 50 ?Gy due to unresectable extensive lesion. One of 18 patients was treated by total resection alone.Results The median of follow up time was 26 months with a range of 0.5～5 years. Sixteen patients (8.9%) are disease free. One patient developed local recurrence and one died of malignant progression. These two patients were treated with radiotherapy alone or surgery only. The local control rates were 100% (15/15) for patients who were treated with surgery and radiotherapy. Conclusions Postoperative radiotherapy is able to decrease the local recurrence rate in dermatofibrosarcoma protuberans.

关 键 词：隆突性皮肤纤维肉瘤 放射治疗 DFSP 

分 类 号：R739.5[医药卫生—肿瘤] R730.55[医药卫生—临床医学]