胰岛内分泌细胞及其肿瘤某些抗原表达的定位研究  

Significance of the expression of some antigens in pancreatic endocrine tumors

作　　者：虞积耀[1] 王育红[1] 王鲁平[2] 王洪海[3] 姚光大 Bordi C 

机构地区：[1]海军总医院,北京100037 [2]北京军区总医院 [3]空军总医院4309医院 [4]意大利帕马大学病理研究所

出　　处：《诊断病理学杂志》2000年第4期263-265,I068,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的　对正常胰岛及胰岛细胞瘤的某些抗原进行检测 ,并对其临床病理意义进行探讨。方法　采用免疫组化方法对正常胰岛细胞及 5 2例胰岛肿瘤的α 人绒毛膜促性腺激素 (α HCG)、孕激素受体 (PR) ,7B2 ,HISL 19,抗原进行定位观察。结果　发现α HCG在正常胰岛细胞不表达 ,在良性胰岛细胞瘤表达为 3/ 2 8(10 7% ) ;恶性胰岛细胞瘤为 14/ 2 4(5 8 3% )。PR分别为 2 0 / 2 8(71 4% )及 7/ 2 4(2 9% ) ;7B2分别为 2 3/ 2 8(82 1% )及 13/ 2 4(5 4 7% ) ;HISL 19分别为 2 3/ 2 8(82 1% )及 11/ 2 4(4 6 % )。Objective To study the expression of some antigens in pancreatic islets and pancreatic endocrine tumors (PETs). Methods The antigens including alpha-subunit of human chorionic gonadotropin (α-HGG), progesterone receptor (PR), 7B2 and HISL-19 were investigated by immunohistochemistry in normal pancreatic islets and in 52 cases of PETs. Results α-HGG was not detected in normal pancreatic islets, but expressed in 3 of 28 (10.7%) cases of benign PETs and 14 of 24 (58.3%) malignant PETs. Expression of PR, 7B2 and HISL in benign PETs were 71.4%, 82.1% and 82.1%, and in malignant PETs, 29%, 54.2% and 46%, respectively. Conclusion Expression of the above antigens may be valuable in the differential diagnosis of benign from malignant PETs.

关 键 词：胰腺内分泌肿瘤 肿瘤抗原 免疫组织化学 

分 类 号：R736.7[医药卫生—肿瘤] R730.2[医药卫生—临床医学]