2,4-二氟联苯的Friedel-Crafts乙酰化工艺研究  

Study of the Friedel-Crafts Acetylation Reaction of 2,4-Difluorobiphenyl

作　　者：瞿军[1] 陈志荣[2] 何玉生 王晓冬 

机构地区：[1]江苏省化工研究所,江苏南京210024 [2]浙江大学化工学院,浙江杭州310027 [3]商丘市进口商品检验局,河南商丘476100

出　　处：《精细化工》2000年第11期637-639,共3页Fine Chemicals

摘　　要：研究了 2 ,4 二氟联苯的Friedel Crafts酰化反应的特性。确定了该反应的最佳条件为 :t=2 0℃ ,n(AlCl3)∶n(2 ,4 二氟联苯 ) =2 5∶1 0 ,t=2 5～ 3.0h。在最佳反应条件下 ,收率≥ 93% ,w〔4 (2′,4′ 二氟苯基 ) 苯乙酮〕 =98%。The Friedel-Crafts acetylation reaction of 2,4 difluorobiphenyl was studied.The optimum technological conditions were determined that the reaction was conducted at 20 ℃ and n (AlCl\-3)∶ n (2,4 difluororbiphenyl)=2 5∶1 0.Under these conditions,the reaction was finished in about 2.5-3 h.The yield was higher than 93% and the purity of the product was 98%.

关 键 词：二氟苯基 苯乙酮 F-C乙酰化 二氟联苯 工艺 

分 类 号：TQ242.1[化学工程—有机化工]