纳米颗粒诱导的自噬效应及在生物医药领域的应用  

Induction of autophagy by nanoparticles and their application in biomedicine

作　　者：崔之芬 诸颖[2] 李晓明[2,3] 孔华庭[2] 陈楠[2] 孙艳红[2] 盛春[1] 樊春海[2] 黄庆[2] 

机构地区：[1]上海师范大学生命与环境科学学院,上海200233 [2]中国科学院上海应用物理研究所物理生物学室,上海201800 [3]中国科学院大学,北京100049

出　　处：《科学通报》2013年第34期3521-3529,共9页Chinese Science Bulletin

基　　金：国家重点基础研究发展计划(2012CB825800;2012CB932600;2012CB825805);国家自然科学基金(11275251;U1232113;U1232114;11179004)资助

摘　　要：自噬是细胞自身调节维持稳态的重要过程,对机体具有重要的生理及病理学作用,是当今生命科学领域的研究热点之一.随着纳米技术在生物医药领域日益广泛的应用,纳米颗粒诱导的自噬效应也引起了研究人员的关注,成为纳米毒理和纳米医药研究领域中一个新的研究方向.本文扼要介绍了细胞自噬的基本情况,包括自噬的种类、诱导因素、自噬的调节和参与基因以及自噬在生命科学中的重要意义.按照纳米颗粒的种类,重点阐述了纳米颗粒诱导的自噬效应及其在生物医药领域的应用,指出在进一步的研究中,应有效调控纳米颗粒引发的自噬效应,从而更好地抵御疾病,促进健康.Autophagy, an important mechanism for maintaining cellular homeostasis, extensively participates in many physiological and pathological processes, and has become one of the hotspots in life sciences research. With more and more extensive application of nanoscience and nanotechnology to biomedicine, induction of autophagy by nanoparticles has attracted much attention by scientists and it becomes a new research direction in nanotoxicology and nanomedicine. This paper briefly introduces the basic situation of autophagy, including types of autophagy, internal/external stimuli, autophagy regulation and associated genes, as well as the great importance of autophagy in life sciences. According to the species of nanoparticles, it focuses on the induction of autophagy by nanoparticles and their application in biomedicine. It is pointed out that in further studies, autophagy induced by nanoparticles should be effectively regulated to prevent disease and promote health.

关 键 词：纳米颗粒 自噬 生物医药领域 “双刃剑” 调控 

分 类 号：R363[医药卫生—病理学] Q25[医药卫生—基础医学]