Preparation and in vitro Release Properties of Mercaptopurine Drug-loaded Magnetic Microspheres  

作　　者：XU Haixing ZHANG Yu NIU Xiaoqian WANG Ling CHEN Hui ZHANG Xi TANG Qiuhan HUANG Zhijun LIU Hui XU Peihu 

机构地区：[1]Department of Pharmaceutical Engineering,School of Chemical Engineering,Wuhan University of Technology [2]Engineering Technology Center of Hubei traditional Chinese medicine preparation

出　　处：《Journal of Wuhan University of Technology(Materials Science)》2013年第6期1231-1235,共5页武汉理工大学学报（材料科学英文版）

基　　金：Funded by the Natural Science Foundation of Hubei Province(No.2011CDA056);the International Cooperation Funding of Hubei Province(No.2012IHA0120);the Fundamental Research Funds for the Central Universities of China(2012-IV-029);the Undergraduate innovation Funding of Wuhan University of Technology(136620004)

摘　　要：Magnetic Fe304 nanoparticles were synthesized by co-precipitation method and the mercaptopurine （MER） drug-loaded magnetic microspheres were obtained through emulsion cross-linking methods. The efficiency of this approach was evaluated in terms of drug loading content （DLC）, encapsulation efficiency （EE） and delivery properties in vitro, determined by high performance liquid chromatograph （HPLC）. The microspheres showed good DLC values of 11.8%, as well as good EE values of 79.4%. The in vitro drug release study was carried out in phosphate buffer solution （PBS） simulated body fluid, at 37 ~C with pH=7.4. The release profiles showed an initial fast release rate, which decreased as time progressed and about 84 % had been released after 48 h. The experimental results indicated that the prepared magnetic microspheres may be useful for potential applications of MER for magnetically targeted chemotherapy.Magnetic Fe304 nanoparticles were synthesized by co-precipitation method and the mercaptopurine （MER） drug-loaded magnetic microspheres were obtained through emulsion cross-linking methods. The efficiency of this approach was evaluated in terms of drug loading content （DLC）, encapsulation efficiency （EE） and delivery properties in vitro, determined by high performance liquid chromatograph （HPLC）. The microspheres showed good DLC values of 11.8%, as well as good EE values of 79.4%. The in vitro drug release study was carried out in phosphate buffer solution （PBS） simulated body fluid, at 37 ~C with pH=7.4. The release profiles showed an initial fast release rate, which decreased as time progressed and about 84 % had been released after 48 h. The experimental results indicated that the prepared magnetic microspheres may be useful for potential applications of MER for magnetically targeted chemotherapy.

关 键 词：MERCAPTOPURINE magnetic microspheres drug loading content encapsulation efficiency 

分 类 号：TQ460.1[化学工程—制药化工]