帕金森病与肌张力障碍患者内苍白球神经元振荡活动特点  

Oscillatory neuronal activity in the globus pallidus internus in patients with Parkinson＇s disease anddystonia

作　　者：崔滨[1] 庄平[1] 张宇清[1] 李建宇[1] 李勇杰[1] 

机构地区：[1]北京,首都医科大学宣武医院,北京功能神经外科研究所,教育部神经变性病重点实验室,100053

出　　处：《中华神经外科杂志》2013年第12期1191-1195,共5页Chinese Journal of Neurosurgery

基　　金：国家自然科学基金资助（30770746,81171061,81371256）

摘　　要：目的探讨帕金森病（PD）与肌张力障碍（Dys）内苍白球（GPi）神经元振荡活动特点。方法13例PD患者、6例Dys患者行GPi毁损术或刺激电极埋植术时应用微电极记录技术采集神经元电活动。峰间隔、峰间隔变异系数和功率谱分析神经元放电及振荡活动特点。结果在PD124个神经元中40．3％伴有振荡活动，17．7％为震颤节律，22．6％为B节律，主要分布在距靶点3．5mm处。在Dys78个神经元中24．4％伴有振荡活动，14．1％为低频节律，10．3％为B节律，主要分布在距靶点6．1ram处。13振荡活动神经元比例和频谱PD都高于Dys（P〈0．05）。结论GPi腹后侧是改善PD的最佳靶点，而背旁侧可能有效改善Dys，支持运动障碍病病理生理假说。Objective To explore neuronal oscillatory activity in the globus pallidus internus （GPi） in patients with Parkinson＇s disease （PD） and dystonia （Dys）. Methods 13 PD patients（M：10, F：3; mean age：60. 3 ：t：4. 5 years, mean disease duration： 7.6 ± 3.5 years） and 6 Dys patients （ M：3, F：3; mean age：31.0 ± 10. 9 years; mean disease duration：9. 8 ± 6. 0 years） who underwent pallidotomy or GPi deep brain stimulation（DBS） were studied. Microelectrode recordings in GPi were performed. Single - unit analysis, inter- spike interval（ISI） and coefficient of variation of ISI （CV） were applied. Power spectral analysis was used to evaluate neuronal oscillation. Results 124 neurons were identified from PD. Of these neurons, 40. 3% neurons had oscillatory activity, 17. 7% neurons discharged as same frequency as tremor （4. 0 ～ 7. 0 Hz） （TFB） oscillation and 22. 6% neurons discharged [3 frequency （ 8 ~ 30 Hz） （[3FB） oscillation. Majority of these oscillatory neurons localized at a distance of 3.5 mm from the final target. 78 neurons were identified from Dys. Of these neurons, 24. 4% neurons had oscillatory activity, 14. 1% neurons had low frequency（0. 5 ~ 3.5 Hz） oscillation （LFB） and 10. 3% neurons had [~FB oscillation. Most of them localized at a distance of 6. 1 mm from the final target. The significant differences of the proportion of oscillatory neurons and neurons with I3FB oscillation （40. 3% vs 24.4% ;22. 6% vs. 10. 3% ） as well as the frequency of [3FB oscillatory activity （8 -30 Hz vs. 11 ~ 22 Hz） approached between PD and Dys（ X2 , P 〈 0. 05 ）, respectively. Furthermore, the significant difference of mean neuronal firing rate reached between PD and Dys （75.4 _＋ 25.8 vs. 38. 6 _＋ 11.5 ） Hz （ P 〈 0. O1 ）. Conclusions The results support the view that the basal ganglia dysfunction is involved to the pathophysiology of PD and Dys. The localizations of oscillatory neuron within the GPi in PD and Dys indicate that the v

关 键 词：帕金森病 肌张力障碍 苍白球 微电极 振荡 

分 类 号：R742.5[医药卫生—神经病学与精神病学]