自身免疫性肝炎的研究进展  

Advances in research of autoimmune hepatitis

作　　者：黄颖秋[1,2] 

机构地区：[1]中国医科大学第五临床学院 [2]本溪钢铁(集团)总医院消化内科,辽宁省本溪市117000

出　　处：《世界华人消化杂志》2013年第33期3670-3677,共8页World Chinese Journal of Digestology

摘　　要：自身免疫性肝炎(autoimmune hepatitis,AIH)是免疫介导的肝脏慢性炎症性疾病,以血清高球蛋白血症、自身抗体阳性、组织学示界面性肝炎以及对免疫抑制剂治疗应答为特征.本文系统阐述了遗传易感性、诱发因素、分子模拟、肝细胞损伤及免疫调节失衡在AIH发病机制中的作用.此外,本文还详尽阐述了AIH的临床特征、血清学特征、组织学特征、诊断以及治疗领域的最新研究进展.Autoimmune hepatitis （AIH） is a chronic in- flammatory disease of the liver triggered by an immune-mediated attack, characterized by the presence of hypergammaglobulinemia, serum autoantibodies, interface hepatitis on histologi- cal examination, and good response to immuno- suppressive therapy. In this article, we will re- view the role of genetic susceptibility, inducing factors, molecular mimicry, liver injury, and im- mune regulation imbalance in the pathogenesis of AIH. In addition, this article systematically describes the advances in research of AIH in terms of clinical features, serological characteris- tics, histologic features, diagnosis and therapy.

关 键 词：自身免疫性肝病 自身免疫性肝炎 遗传易感性 分子模拟 免疫调节 诊断 治疗 

分 类 号：R575.1[医药卫生—消化系统]