接头蛋白SH2B1和RhoA蛋白在食管癌患者中的表达及临床病理意义  

Clinicopathologic significance of SH2B1 and RhoA expression in esophageal cancer

作　　者：姜齐宏[1] 陈艳[1] 王爱祥[1] 

机构地区：[1]华中科技大学同济医学院附属普爱医院消化内科,湖北省武汉市430034

出　　处：《世界华人消化杂志》2013年第33期3706-3709,共4页World Chinese Journal of Digestology

摘　　要：目的:研究食管癌组织中接头蛋白SH2B1和RhoA的表达及临床病理意义.方法:应用免疫组织化学方法检测SH2B1和RhoA在食管癌组织及正常组织中的表达情况.结果:134例食管癌组织中SH2B1和RhoA阳性表达率显著性高于正常组织(84.2%vs33.6%,P=0.028<0.05;79.8%vs 22.4%,P=0.022<0.05),且SH2B1,RhoA表达与浸润程度,TNM分期及淋巴结转移有关(P<0.05),与患者性别、年龄、肿瘤类型、分化程度无关(P>0.05).结论:SH2B1、RhoA在食管癌组织中高表达,且与食管癌临床病理学特征有着密切关系.AIM： To detect the expression of SH2B1 and RhoA in esophageal cancer and to analyze their clinicopathologic significance. METHODS： The expression of SH2B1 and RhoA in esophageal cancer tissues and normal tissues was detected by immunohistochemistry. RESULTS： The positive rates of SH2B1 and RhoA expression were significantly higher in esophageal cancer tissues than in the normal tis- sues （84.2% vs 33.6%, P = 0.028; 79.8% vs 22.4%, P = 0.022）. SH2B1 and RhoA expression levels were correlated with depth of invasion, TNM stage and lymph node metastasis （all P 〈 0.05）, but not with gender, age, tumor type or histo- logical grade （all P 〉 0.05）.CONCLUSION： High expression of SH2B1 and RhoA is detectable in esophageal cancer tissues. The expression of SH2B1 and RhoA has close as- sociations with clinicopathologic characteristics of esophageal cancer.

关 键 词：食管癌 SH2B1 RHOA 

分 类 号：R735.1[医药卫生—肿瘤]