胃肠间质瘤30例临床病理分析  

Clinicopathological features of gastrointestinal stromal tumor

作　　者：张喜卿[1] 王志成[1] 初霞[1] 王巧云[1] 薛江波[1] 

机构地区：[1]解放军153医院病理科,郑州450042

出　　处：《诊断病理学杂志》2013年第12期756-759,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨胃肠间质瘤(GIST)的临床病理特点及免疫组化特征。方法分析30例GIST的临床资料和免疫组化结果。结果 30例GIST中,男性19例,女性11例,年龄24～75岁,平均年龄53.2岁。15例发生于胃,3例位于食管,9例位于空肠和十二指肠,2例位于结肠,1例位于肠系膜。良性12例,恶性12例,交界性6例。临床表现为腹胀、腹痛、腹部包块、血便等。30例中梭形细胞型20例,上皮细胞型6例,混合细胞型4例。免疫组化:28例CD117(+),27例DOG1(+),25例CD34(+),vimentin30例全部(+),3例SMA(+),2例desmin(+),1例S-100(+)。结论胃肠道间质瘤好发于中老年人,CD117、DOG1和CD34联合检测可提高GIST的诊断率,手术是重要和有效的治疗方法。Objective To study the clinicopathological and immunohistochemical characteristics of gastrointestinal stromal tumor（ GIST）. Methods The clinical data were reviewed in 30 cases of GIST regarding the clinical features and immunohistochemical staining. Results Of 30 cases,age ranged from 24 to 75 years（ mean 53. 2 years）,including 19males and 11 females. There were 15 cases in stomach,9 in small intestine,3 in esophagus,2 in colon,and 1 in mesenterium. In 30 patients,12 cases were benign,12 cases were malignant,and 6 cases were borderline. The clinical manifestations of GIST were abdominal distension or pain,abdominal masses and gastrointestinal bleeding. Histologically,there were 20 cases of spindle cell type, 6 cases of epithelioid cell type and 4 cases of mixed cell type.Immunohistochemically,the expression rates of CD117,DOG1,CD34,vimentin,SMA,Des and S-100 protein were93. 3%（ 28 /30）,90. 0%（ 27 /30）,83. 3%（ 25 /30）,100. 0%（ 30 /30）,10. 0%（ 3 /30）,6. 7%（ 2 /30） and 3. 3%（ 1 /30）,respectively. Conclusion GIST predominantly occurs in middle- aged and older patients. Combined detection of CD117,DOG1 and CD34 may improve its accurate diagnosis rate. Surgery is the principal and effective procedure for this tumors.

关 键 词：胃肠间质瘤 临床病理 免疫组化 

分 类 号：R735.2[医药卫生—肿瘤]