定量脑电图对急性脑梗死静脉溶栓治疗患者脑功能的评估作用  

Evaluation of quantitative EEG on brain function in acute cerebral infarction patients with intravenous thrombolysis

作　　者：杨娟[1] 白青科[1] 赵晓晖[1] 陈娟[1] 朱玉萍[1] 李锦师[1] 陈翠荣[1] 陆练军[1] 沈健[1] 夏卫英[1] 隋海晶[1] 

机构地区：[1]浦东新区人民医院神经内科,上海201200

出　　处：《临床神经病学杂志》2013年第6期408-410,共3页Journal of Clinical Neurology

基　　金：上海市浦东新区卫生局青年基金(PWZ2011B-7);浦东新区卫生系统重点学科建设基金(PWZAK2010-03);上海市浦东新区卫生系统医领先人才培养基金(PWRDJ2007-02)

摘　　要：目的探讨定量脑电图(QEEG)对急性脑梗死静脉溶栓治疗患者脑功能的评估作用。方法给予30例急性脑梗死患者(溶栓治疗组)重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓治疗,在治疗前、治疗后2 h、24 h、7 d、14 d、90 d进行QEEG检查和美国国立卫生研究院卒中量表(NIHSS)评分;计算EEG大脑对称指数(BSI)及δ+θ波与α+β波的比率(DTABR);并与40例常规治疗的急性脑梗死患者(对照组)进行比较。结果与治疗前比较,溶栓治疗组的BSI从治疗后24 h、DTABR及NIHSS评分从治疗后7 d起各时间点均明显减低(改善)(P<0.05～0.01);而对照组则分别从治疗后7 d、14 d、14 d起减低(均P<0.05)。溶栓治疗组治疗后各时间点BSI、治疗后24 h、7 d的DTABR及治疗后7 d～90 d的NIHSS评分均明显低于对照组(P<0.05～0.01)。结论 QEEG能准确反映急性脑梗死患者静脉溶栓治疗后脑功能的改善,而且明显要早于临床神经功能缺损评分;其中以BSI的敏感性更高。Objective To explore the evaluation of quantitative EEG （QEEG） on brain flmction in acute cerebral infarction patients with intravenous thrombolysis. Methods Thirty cases of acute cerebral infarction were treated with recombinant tissue plasminogen activator （rt-PA） intravenous thrombolytic therapy （thrombolysis group）. Before and 2 h,24 h,7 d, 14 d,90 d after the treatment, the patients were examined by QEEG and the United States National Institutes of Health Stroke Scale （NIHSS） score; EEG brain symmetry index （BSI） and the radio δ＋θand α＋β wave （DTABR） were calculated. The results were compared with 40 cases of acute cerebral infarction treated with normal therapy （control group）. Results Compared with those before treatment, in the thrombolytisis group, BSI at each time point after 24 h after treatment, DTABR and NIHSS scores at each time point after 7 h after treatment were significantly decreased （ improved ） （ P 〈 0. 05 - 0. 01 ）. But control group＇s data decreased respectively from the 7 d , 14 d, 14 d after treatment （ all P 〈 0. 05 ）. In the thrombolytisis group, BSI at 24 h after treatment,DTABR at 24 h and 7 d and NIHSS score of 7 d -90 d were significantly lower than those in the control group （ P 〈 0. 05 - 0. 01 ）. Conclusion QEEG can accurately reflect the brain function improvement of intravenous thrombolytic therapy in acute cerebral infarction patients, it is earlier than the clinical neurological deficiency scores; and the sensitivity of BSI is higher.

关 键 词：急性脑梗死 静脉溶栓 定量脑电图 

分 类 号：R743.3[医药卫生—神经病学与精神病学]