环境因素和CYP2E1基因rs8192775位点的交互作用与汉族人群胃癌的关系  

Relationship between CYP2E1 gene rs8192775 polymorphism and interaction of gene-environment and susceptibility of gastric cancer

作　　者：蒋林 王佳[2] 任晓峰[2] 颜小銮 王凡[2] 沈孝兵[2] 

机构地区：[1]南京铁路疾病预防控制中心,江苏南京210042 [2]东南大学公共卫生学院教育部环境医学工程重点实验室,江苏南京210009

出　　处：《东南大学学报（医学版）》2013年第6期728-732,共5页Journal of Southeast University(Medical Science Edition)

基　　金：国家自然科学基金资助项目(81172619);江苏省自然科学基金资助项目(BK2009283)

摘　　要：目的:探讨环境因素和CYP2E1基因rs8192775位点以及二者交互作用与汉族人群胃癌的关系。方法:采用1∶1病例对照研究,选择经病理确诊的汉族原发性胃癌新发患者330例及其对照进行流行病学资料调查。应用多重高温连接酶检测反应技术(iMLDR)检测rs8192775位点基因型并分析环境因素、rs8192775位点多态性及其基因-环境的交互作用与胃癌的关系。结果:胃癌的环境危险因素为消化系统疾病史、肿瘤家族史、三餐不定时、喜食烟熏煎炸食品和精神压抑,保护因素为喜食新鲜水果。病例、对照组之间基因型频率的差异有统计学意义(P<0.05)。环境因素与rs8192775在胃癌的发生中均存在显著的交互作用(P int<0.05)。结论:消化系统疾病史、肿瘤家族史、喜食新鲜水果、精神压抑与rs8192775位点存在交互作用,增加易感个体胃癌的发生风险。Objective：To determine the association of CYP2E1 gene rs8192775 polymorphism and interaction of gene-environment with the susceptibility of gastric cancer in Han nationality .Methods：A case-control study was conducted to collect 330 new cases of primary gastric cancer and control of epidemiological data and clinical pathology .To apply conditional Logistic regression analysis for environment influence factors in Han population of Nanjing city, multiple heat ligase detection reaction technology （iMLDR） was applied to detect rs8192775, using crossover analysis method to analyse the interaction of SNPs locus and the environment risk factors .Results： The environmental risk factors concluded history of digestive disease , family history of cancer , irregular meals , smoked fried foods and mental depression , fresh fruits were protective factors .The differences of genotype frequency between two groups were statistically significant （ P 〈0.05 ） . The environment factors with rs 8192775 had significant interaction in the occurrence of gastric cancer （Pint 〈0.05）.Conclusion：The interaction of rs8192775 polymorphism and environmental risk factors happens in gastric cancer .

关 键 词：胃癌 单核苷酸多态性 环境因素 交互作用 

分 类 号：R735.2[医药卫生—肿瘤]