32例原发性乳腺神经内分泌癌的临床及病理分析  

Clinical and Pathologic Analysis of 11 Cases of Primary Breast Neuroendocrine Carcinoma

作　　者：朱美琴[1,2] 周文斌 申维玺[1,2] 夏俊贤[1,2] 徐敏 陈敬华[1,2] 

机构地区：[1]暨南大学第二临床医学院 [2]深圳市人民医院肿瘤内科,广东深圳518020 [3]深圳市人民医院乳腺甲状腺外科,广东深圳518020

出　　处：《中国医药指南》2013年第32期12-13,共2页Guide of China Medicine

摘　　要：目的探讨乳腺内分泌癌的临床及病理特征。方法回顾性分析2006年6月至2012年11月收治的32例女性乳腺神经内分泌癌的临床特征、病理、治疗及预后。结果患者的平均年龄为53.6岁,雌激素受体(ER)和孕激素受体(PR)阳性表达率较高,人类表皮生长因子受体2(HER2)为(-)^(++)。免疫分型15例为LuminalA型,17例为Luminal B型。12例患者接受乳腺癌根治术,20例患者接受乳腺癌改良根治术。32例均获随访,随访时间4~70个月,中位随访时间为30个月,均存活,无复发及远处转移。结论乳腺神经内分泌癌好发于老年女性,其免疫分型可能与预后相关,手术治疗和综合治疗的疗效较好,总体预后较好。Objective To investigate the clinical and phathologic characteristics of breast neuroendocrine carcinoma. Methods 32 patients with breast neuroendocrine carcinoma were admitted from June 2006 to November 2012.Their clinical and pathological data,treatment and prognesis were analyzed retrospectively. Results The average age of the 32 patients was 53.6 years. The expressions of hormone receptors like ER（estrogen receptor）/PR（progesterone receptor）were usually positive in NEC,while the expression of HER2（human epidermal growth factor receptor 2） was usually negative（-） to positive（＋＋）. In moleculer subtypes,15 patients were Luminal A, 17 patients were Luminal B.12 patients received radical mastectomy,20 patients received modified radical mastectomy.All cases were followed-up average 30 months（range 4~70 months）.All cases were alive with no recurrence and distant metastasis. Conclusions Breast neuroendocrine carcinoma may affect older patients, and moleculer subtypes may be ralated to prognosis.Surgical and comprehensive therapy may achieve satisfactory outcome with relatively good prognosis,

关 键 词：乳腺肿瘤 神经内分泌癌 诊断 治疗 

分 类 号：R737.9[医药卫生—肿瘤]