替莫唑胺联合调强放疗治疗高级别胶质瘤的近期疗效和不良反应的临床观察  

Clinical Observationon on the Short-term Clinical Efficacy and Safety of Temozolomide Combined with Radiotherapy for High Grade Gliomas

作　　者：黄蕾[1] 陈诚[1] 吴俚蓉[1] 吴建峰[1] 

机构地区：[1]江苏省肿瘤医院放疗科,江苏南京210009

出　　处：《中国医药指南》2013年第33期318-319,共2页Guide of China Medicine

摘　　要：目的观察替莫唑胺联合调强放疗治疗高级别胶质瘤的近期临床疗效,评估治疗的安全性。方法对48例高级别脑胶质瘤术后患者进行回顾性研究,分为对照组(n=25)、联合治疗组(n=24)。对照组患者术后行调强放疗,总剂量60Gy;联合治疗组患者行调强放疗的同时口服替莫唑胺75mg/(m2 d)。两组患者治疗过程中每周监测血常规、肝功能及肾功能。结果 49例高级别脑胶质瘤术后患者放化疗结束后随访12个月,联合治疗组的总有效率为79.17%(19/24),对照组的总有效率为41.67%(10/24),两组比较,差异有统计学意义(P<0.05)。联合治疗组患者不良反应较对照组多见,但经对症治疗,可获得缓解,患者能耐受。结论替莫唑胺联合调强放疗治疗术后高级别胶质瘤脑胶质瘤具有协同效应,提高治疗效果,安全可靠。Objective To investigate the short-term clinical efifcacy and safety of postoperative radiotherapy combined with temozolomide chemotherapy in treating high-grade gliomas. Methods Forty-eight patients with high-grade gliomas who had accepted resection were divided into two groups：control group（n=24）and combination treatment group（n=24）. Both groups were given intensity modulated radiotherapy with total dose of 60 Gy and the control group was given additional Temozolomide chemotherapy.The complete blood count,hepatic and renal function of all patients in both group were monitored. Results The total effective rate in the combination treatment group was 79.17%（19/24）,which was 41.67%（10/24）in the control group.The total effective rates were significantly different between the two groups（P〈0.05）.There were more adverse reactions in the combination treatment group than in the control group. Adverse effects could be relieved after symptomatic treatment. Conclusion Intensity modulated radiotherapy combined with Temozolomide chemotherapy for high-grade gliomas can improve curative effects,is safe and reliable.

关 键 词：高级别胶质瘤 调强放疗 替莫唑胺 

分 类 号：R739.41[医药卫生—肿瘤]