可溶性E-和P-选择素与急性脑梗死的关系  

Soluble E- and P-selectins in acute cerebral infarction

作　　者：曾杨滨 杨期东[2] 彭光莹 许治强 

机构地区：[1]广州市第二人民医院神经内科,510150 [2]湖南医科大学附属湘雅医院神经内科,410078

出　　处：《中国急救医学》2000年第12期715-716,共2页Chinese Journal of Critical Care Medicine

摘　　要：目的　探讨E -和P -选择素与脑梗死的关系。方法　用ELISA方法测定 30例脑梗死、2 5例脑出血患者及2 8例正常人的sE -和sP -选择素血清水平 ,分析它们与WBC、N %、TNF及IL - 6血清水平之间的关系。结果　急性期脑梗死患者sE -和sP -选择素血清水平 [分别为 (6 5 2± 39 4)ng/ml、(399± 134)ng/ml]明显高于脑出血患者 [分别为 (4 4 6± 11 8)ng/ml、(2 43± 112 )ng/ml]及正常人 [分别为 (4 0 5± 12 5 )ng/ml、(2 2 7± 10 6 )ng/ml]。而该组患者恢复期这两种选择素水平无明显升高。急性期脑梗死患者sE -和sP -选择素水平分别与WBC、N %、IL - 6水平呈正相关关系 ,sP -选择素水平还与TNF水平呈正相关关系。结论　sE -和sP -选择素血清水平增高反映脑梗死急性期E -和P -选择素可能在TNF和IL - 6的刺激下 。Objective To determine the roles of E-and P-selectins in the pathogenesis of cerebral infarction.Methods The serum concentrations of sE-and sP-selectins were measured with enzyme-linked immunosorbent assay (ELISA)in 30 cerebral infarction、25 cerebral haemorrhage and 28 healthy control subjects.The correlations between selectins and WBC、N%、the serum level of TNF or the serum level of IL-6 were analyzed.Results The serum levels of sE- and sP- selectins in acute stage of cerebral infarction group[(65 2±39 4)ng/ml,(399±134) ng/ml,respectively]were significantly higher than those in acute stage of cerebral haemorrhage[(44 6±11 8)ng/ml,(243±112) ng/ml,respectively] and those in healthy control group[(40 5±12 5)ng/ml,(227±106) ng/ml,respectively].In acute stage of cerebral infarction,the serum concentration of sE- selectin, as well as the level of sP-selectin,was observed in positive correlation with the WBC、N%、or the level of IL-6 respectively.The level of sP- selectin was also positively correlated with the level of TNF.Conclusions The increased levels of sE- and sP- selectins reflected that these two selectins might be enhanced the endotheliocyte-leukocyte adhesion,under the stimulations of TNF and IL-6,so as to be involved in the cerebral injury after acute cerebral infarction.

关 键 词：急性脑梗死 可溶性E-选择素 可溶性P-选择素 

分 类 号：R743.33[医药卫生—神经病学与精神病学]