长春瑞滨加醛氢叶酸和大剂量氟尿嘧啶治疗晚期三阴性乳腺癌  

Changchun vinorelbine plus Leucovorin and high doses of fluorouracil in the treatment of advanced three negative breast cancer

作　　者：庞世权[1] 陈茵[1] 余海清[1] 吴江[1] 林晓辉[1] 张岚[1] 

机构地区：[1]深圳市宝安区人民医院肿瘤科,广东深圳515801

出　　处：《中国现代医生》2013年第34期75-76,79,共3页China Modern Doctor

基　　金：卫生部医药卫生科技项目(44011120102513K)

摘　　要：目的探讨长春瑞滨(NVB)加醛氢叶酸(CF)和大剂量氟尿嘧啶(5-FU)治疗晚期三阴性乳腺癌(TNBC)的疗效。方法选择2010年4月～2012年4月我院收治的35例晚期TNBC患者作为观察对象,给予NVB联合CF、大剂量5-FU进行治疗,观察患者化疗后的有效率、毒副反应、疾病进展时间(TTP)、1年生存率。结果治疗总有效率为74.29%,其中CR为5例,PR为21例,SD为5例,PD为4例,RP为26例。绝经前后有效率分别为40.00%、34.29%;浸润性导管癌和小叶癌有效率分别为42.85%、31.43%;转移灶单个和多个有效率分别为62.85%、8.57%;既往治疗包含紫杉类和不含紫杉类有效率均为37.14%。主要副作用有白细胞下降和口腔溃疡,其中白细胞下降总发生率为60.00%,口腔溃疡总发生率为74.29%,毒副反应大多为Ⅱ～Ⅲ级,在病患可承受范围内,疾病进展时间为(9.5±2.3)个月、1年生存率为(76.36±8.21)%。结论 NVB联合CF、大剂量5-FU治疗TNBC能提高有效率以及患者生存率,安全性较高,值得临床推广应用。Objective To investigate the effect of Changchun vinorelbine （NVB） plus leucovorin （CF） and high dose of 5-fluorouraeil （5-FU） in the treatment of advanced three negative breast cancer （TNBC）. Methods A total of 35 pa- tients with advanced TNBC from April 2010 to April 2012 in our hospital were selected as the study objects, and were given NVB in combination with CF, high dose 5-FU treatment, observed the efficiency, toxicity, disease time progress （TFP）, 1 year survival rate of patients after chemotherapy. Results The total effective rate was 74.29%, included 5 cas- es of CR, 21 cases of PR, 5 cases in SD, 4 cases in PD, 26 cases in RP. Menopause efficiency were 40.00%, 34.29%; invasive ductal and lobular carcinoma efficiency were 42.85%, 31.43%; metastasis of single and multiple efficiency were 62.85%, 8.57%; previous treatment contained taxane and not contained taxane effective rate was 37.14%. The main side effects were neutropenia and oral ulcer, the total occurrence rate of the decrease of white blood cells was 60.00%, oral ulcer occurrence rate was 74.29%, most side effects were II-III grade, the patient can withstand range, time to disease progression was （9.5_＋2.3） months, 1 years survival rate was （76.36_＋8.21）%. Conclusion NVB in com- bination with CF, high dose 5-FU treatment of TNBC can improve the efficiency and the survival rate of the patients, higher security, is worthy of clinical application.

关 键 词：TNBC 长春瑞滨 醛氢叶酸 氟尿嘧啶 晚期 

分 类 号：R575.2[医药卫生—消化系统]