干细胞移植治疗帕金森病的研究进展  

Research progress of stem cell transplantation for parkinson's disease therapy

作　　者：周春辉[1] 王晓晴[2] 张剑宁[1] 

机构地区：[1]海军总医院神经外科,北京100048 [2]第二军医大学附属长海医院神经内科,上海200433

出　　处：《转化医学杂志》2013年第6期341-343,347,共4页Translational Medicine Journal

摘　　要：帕金森病又名震颤麻痹,是一种常见的中老年人神经系统变形性疾病,临床上以静止性震颤、运动迟缓、肌强直和姿势步态异常为主要特征,造成帕金森病症状的主要病理基础是中脑多巴胺神经元的退行性变化。通过脑内移植未分化的多巴胺神经元,替代帕金森病患者坏死的多巴胺神经元,可以使患者症状好转和功能恢复。本文描述干细胞移植治疗帕金森病新的临床试验前景,简要讨论和总结这些在动物实验和人体上进行的试验所得到的结论和新发现,并讨论移植引起的运动障碍、伦理、肿瘤形成等问题,以期解决干细胞移植后的不良反应和并发症。The main pathology basis underlying symptoms in Parkinson＇s disease （PD） is a degeneration of nigrostriatal dopamine （DA） neurons. Intrastriatal transplantation of immature DA neurons, which replace those died neurons,leads to functional restoration for PD patients. The prospect for the new clinical trial with transplantation of stem ceils is described, we briefly summarize and discuss recent findings of these grafts to the animals and human after implantation. We summarize the attempts to generate DA neurons from stem cells of various sources and patient-specific DA neurons from fully differentiated somatic cells, with particular emphasis on the requirements of these cells to be useful in theelinical setting. Finally, we discuss the underlying graft-induced dyskinesias, ethical problems, and secondary tumor formation which constitute the significant adverse events observed after neural transplantation and wish that there will be methods to develop a competitive cell therapy for PD patients.

关 键 词：帕金森病 细胞治疗 干细胞移植 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R329.24[医药卫生—临床医学]