鼻咽癌患者血清一氧化氮水平的变化及临床意义  

Changes of nitric oxide in serum of patients with nasopharyngeal carcinoma and its clinical significnce

作　　者：蔡桦[1] 雷旦生[1] 张顺[1] 

机构地区：[1]湖北省肿瘤医院,湖北武汉430079

出　　处：《中国实验诊断学》2000年第6期271-272,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的　通过８７例鼻咽癌患者血清一氧化氮浓度的观察，研究内源性一氧化氮水平的变化与鼻咽癌病理过程的关 系及其临床意义，探讨一氧化氮在肿瘤免疫方面的作用。方法　采用硝酸还酶法，通过检测血清中ＮＯ－３与ＮＯ－２浓度的总和反 映体内一氧化氮水平。结果鼻咽癌病人血清一氧化氮含量显著高于健康人，前者ｘ±ｓ为１０２．３±７．５，后者仅为７１４± １８．２μ ｍｏｌ／Ｌ（Ｐ＜０．０１）。对４０例鼻咽癌患者同时检测血清一氧化氮和ＥＢ病毒ＶＣＡ—ＩｇＡ抗体结果发现，一氧化氮浓度与 ＶＣＡ抗体的阳性滴度呈正相关。而患者经治疗后或其病灶有远处转移时，一氧化氮水平均呈下降趋势。结论　鼻咽癌患者在 病情发展过程中，血清中一氧化氮的合成、释放及消耗均有所增加。它反映了一氧化氮参与介导肿瘤免疫的过程，同时也表明 在肿瘤细胞增生和扩散过程中，机体抑制和抗肿瘤的能力下降。Objective To study the changes of endogenous nitric oxide (NO) in serum of 87 patients with nasopharyngeal carcinoma (NPC) and the relationship with the pathology and its clinical value. Method The method of nitrifying ferment was used to test the level of NO and total concentration of NO-3 and NO-2, from patients' blood. Results The volume of NO were higher in the Nasopharyngeal carcinoma patients than that in the healthy person. The former's valume was 102.3±7.5,but the latter's was 71.4±8.2μmol/L(P<0.01). NO and virus EB antibody VCA-ICA were tested from 40 NPC patients.The con- centration of NO was correlated with the titre of antibody VCA. After the patients were given radiotherapy or distal metastasis happend, the level of NO was lower. Conclusion In the course of NPC disease, the composition and exhaust of Nitric oxide were enhanced in the body of patients; when tumor cells become proliferous and diffuse,the levels of immuinity and antitu- mor were lower.

关 键 词：一氧化氮 鼻咽癌 血清 浓度 

分 类 号：R739.63[医药卫生—肿瘤]