气相色谱-正化学电离质谱法检测婴儿奶嘴中N-亚硝胺物质的迁移量  

GC-MS(PCI)Determination of Amount of N-Nitrosamines Migrated from Infant Nipple

作　　者：杨荣静[1] 卫碧文[1] 高欢[1] 于文佳[1] 高鹏 

机构地区：[1]上海出入境检验检疫局,上海200135 [2]岛津企业管理(中国)有限公司,上海200052

出　　处：《理化检验（化学分册）》2013年第12期1423-1427,共5页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

摘　　要：提出了气相色谱-正化学电离质谱联用技术检测婴儿奶嘴中12种N-亚硝胺物质的迁移量的方法。样品经人工唾液提取后，过经二氯甲烷活化的活性炭固相萃取柱净化。在气相色谱分离中用DB-Wax色谱柱为固定相，在质谱分析中采用全扫描和选择离子监测模式。12种N-亚硝胺物质的峰面积与质量浓度均在0．01～5．0mg·L^-1范围内呈线性关系，方法的测定下限（10S／N）均为0．001mg·kg^-1。以奶嘴样品为基体做加标回收试验，测得12种N-亚硝胺物质的回收率在89．3％～95．6％之间，相对标准偏差（n=7）在3．6％～7．6％之间。A method of Cd2-MS（PC1） for the determination of amount of 12 N-nitrosamines migrated from infant nipple was proposed. The sample was extracted with artificial saliva solution,and the extract was purified by passing through activated carbon SPE column which was pre-activated by dichloromethane. The DB-Wax column was used for GC separation, and the full-scanning mode and selected ion monitoring mode were adopted in MS determination. Linear relationships between values of peak area and mass concentration of the 12 N-nitrosamines were kept in the same range of 0. 01- 5. 0 mg ·^L^-1, with same lower limit of determination （10S/N） of 0. 001 mg · kg^-1. Using nipple sample as matrix, test for recovery was made by standard addition method, giving recovery of the 12 N nitrosamines in the range of 89. 3%-95. 6%, with RSD＇s （n=7）in the range of 3. 6%- 7.6%.

关 键 词：气相色谱-正化学电离质谱法 N-亚硝胺 婴儿奶嘴 

分 类 号：O657.7[理学—分析化学]