HTR2A基因多态性与云南彝族酒精依赖关联性研究(英文)  

Association Study of Human Serotonin 5-HTR2A gene Polymorphisms with Alcohol Dependence in Yunnan Yi Population

作　　者：杨浩[1] 钟树荣[1] 赵丽娟[1] 李金华[1] 曾熙然 景强[1] 

机构地区：[1]昆明医科大学,云南昆明650000 [2]约克大学

出　　处：《现代生物医学进展》2013年第33期6430-6434,共5页Progress in Modern Biomedicine

基　　金：National science foundation of China(30960115;81000577);Natural science fund of Yunnan province(2009CD080)~~

摘　　要：目的:探讨酒精依赖和云南彝族5-羟色胺2A受体(HTR2A)基因多态之间的关系。方法:采用PCR-RFLP技术对330健康人(对照组)和110名酒精依赖者(病例组)的5-HT2A受体基因的遗传多态性进行检测。结果:在440例样本中共检测到2种等位基因A和G,三种基因型AA,AG,GG.三种基因型在对照组中频率分别是38.5%,55.8%,5.8%;在病例组中的频率分别是30%,63.6%,6.4%。结论:在云彝族人群中,HTR2A基因rs6311(A-1438G)位点与酒精依赖无显著关联,HTR2A基因rs6311(A-1438G)位点在云南汉族和云南彝族酒精依赖组中无显著差异,但是在健康对照组中存在关联性.Objective： To investigate the relationship between alcohol dependence and polymorphism of serotonin receptor 2 a （5-HTR2A） gene rs6311 in Yunnan Yi population. Methods： The PCR-RFLP was used to analyze genetic polymorphism of 5-HT2AR gene, the genotype and gene frequencies in 330 control groups and 110 AD groups. Results： Two alleles of the 5-HT2AR gene were detected in 440 samples： alleles A and G., including three genotypes： AA, AG and GG. Genotype frequency was 30%, 63.6%, 6.4% in AD groups, and 38.5%, 55.8%, 5.8% in control groups, respectively. Conclusion： There was no significant association for HTR2A gene rs6311 between AD group and control group in Yunnan Yi Population.

关 键 词：酒精依赖 HTR2A 基因多态性 云南彝族 

分 类 号：R394[医药卫生—医学遗传学] Q75[医药卫生—基础医学]