内皮祖细胞治疗急性脑梗死的临床研究进展  

Clinical Research Development of Circulating Endothelial Progenitor Cells in Acute Cerebral Infarction

作　　者：陈瑞芳[1] 罗勇[1] 

机构地区：[1]重庆医科大学附属第一医院神经内科,重庆市神经病学重点实验室,重庆400016

出　　处：《中国卒中杂志》2013年第12期988-992,共5页Chinese Journal of Stroke

基　　金：重庆市卫生局中医药科技重点项目(ZY20131027);教育部"高等学校博士学科点专项科研基金"联合资助课题(20095503110001);重庆市卫生局中医药科研项目(2005B24)

摘　　要：内皮祖细胞(endothelial progenitor cells,EPCs)作为成年个体血管再生的前体细胞,在脑缺血时,可从骨髓动员至外周血并靶向归巢至缺血区,参与修复和改善脑组织微循环,为神经功能的恢复和重建打下基础。EPCs已成为目前治疗脑梗死和协助评价脑梗死临床预后较新颖且有效的靶点。本文就EPCs在急性脑梗死方面的保护机制及近年来的临床活化策略做一综述。Endothelial progenitor cells （EPCs） are adult vascular regeneration precursor cells. They can be mobilized from bone marrow into the circulation and homing to the ischemic area so as to participate in repairing and improving cerebral microcirculation during cerebral ischemia, which lay the foundation for the neural function recovery and reconstruction. EPCs have been documented to be a novel and effective target for treating and assisting in clinical prognostic judgment of acute cerebral infarction. In this paper, the protection mechanism of EPCs in ischemic cerebrovascular disease and the clinical activation strategies for using them to treat ischemic stroke were reviewed.

关 键 词：急性脑梗死 内皮祖细胞 血管再生 神经血管单元 

分 类 号：R743.3[医药卫生—神经病学与精神病学]