曲唑酮治疗失眠的临床评价  

Clinical evaluation of trazodone in the treatment of insomnia

作　　者：蔡俊颖[1] 

机构地区：[1]福建医科大学附属泉州第一医院神经内科,福建泉州362000

出　　处：《中国临床药理学杂志》2013年第12期914-916,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察失眠患者使用曲唑酮后的睡眠情况,评价曲唑酮治疗失眠的临床疗效。方法将入组90例患者分为A、B、C 3组,每组30例,分别服用阿米替林50 mg,曲唑酮50 mg,曲唑酮100 mg,每晚1次,治疗4周。患者初诊及随访时检测抑郁焦虑量表(HAMA、HAMD)、睡眠匹兹堡量表(PSQI),同时记录睡眠情况和不良反应(TESS量表),比较3组治疗效果。结果 B组和C组患者总睡眠时间延长,睡眠潜伏期缩短,觉醒次数减少,HAMA、HAMD和PSQI分值下降,均优于A组患者。结论唑酮治疗失眠有显著疗效。Objective To observe the sleep quality of insomniac after using trazodone and evaluate the clinical efficacy of trazodone in the treatment of insomnia. Methods Ninty patients were divided into A,B,C group,30 cases in each group,respectively,taking amitriptyline in 50 mg, trazodone in 50 mg and trazodone in 100 mg,quaque nocte,for 4 weeks. Patients were detected with scales such as HAMA,HAMD and pittsburgh sleep quality index in the initial diagnosis and followup process,at the same time recorded sleep diary and adverse reaction（ TESS scale）. The treatment effects were compared among the 3 groups. Results The total sleep time were longer in group B and group C,meanwhile the sleep latency and wake times reduces,HAMA,HAMD and PSQI score decreased, the indexes above were all better than group A. Conclusion There are significant effects for trazodone in the treatment of insomnia.

关 键 词：曲唑酮 失眠 焦虑 抑郁 药物不良反应 

分 类 号：R749.71[医药卫生—神经病学与精神病学] R969.4[医药卫生—临床医学]