子宫颈癌放疗同步化疗治疗中顺铂用药临床观察  

Clinical Observation of Cisplatin in Cervical Cancer Radiotherapy Synchronous Chemotherapy

作　　者：张文陆[1] 王言[1] 崔慧霞[2] 

机构地区：[1]辽宁医学院附属第一医院综合八病区,辽宁锦州121001 [2]辽宁医学院护理学院,辽宁锦州121001

出　　处：《中国医科大学学报》2013年第12期1087-1090,共4页Journal of China Medical University

基　　金：辽宁省博士启动基金(20121095);辽宁医学院博士启动基金(Y2012B018)

摘　　要：目的观察放疗与顺铂同步化疗治疗子宫颈鳞癌中,顺铂用药周期数、用药剂量、近期疗效和不良反应方法回顾分析51例Ib1~Ⅲb期子宫颈鳞癌患者,行盆腔野放疗(剂量45~50 Gy/5周),同时应用顺铂每周方案(顺铂30 mg/m^2,每周1次,静脉滴注)进行化疗,35例Ib1~Ⅲb子宫颈鳞癌单纯放疗,观察其近期疗效和不良反应,记录放化同步治疗组患者应用顺铂的周期数及顺铂剂量。结果应用DDP30 mg/m^2每周1次放疗化疗同步治疗的中位化疗周期为4周,与单纯放疗组相比,放化同步治疗患者的白细胞计数显著低于放疗组,恶心呕吐的发生率显著高于放疗组,差异具有统计学意义(P<0.05),但是远期疗效中,同步组3年无病生存率92.7%,5年无病生存率61.4%,放疗组3年无病生存率86.8%,5年无病生存率54.4%,2组差异具有统计学意义(P=0.038)。结论放疗化疗同步治疗子宫颈鳞癌时,顺铂用药量为顺铂30 mg/m^2,每周1次,静脉滴注,行4周化疗对宫颈癌治疗有着较好的临床疗效。Objective To observe the number of cycles of cisplatin medication, medication dose, efficacy and adverse reactions in the chemothera- py of cervical cancer radiotherapy synchronous. Methods A relxospeetive analysis was performed, including 51 cases of I bl to the Ⅲb phase cer- vical cancer patients with pelvic field radiotherapy （dose of 45 to 50 Gy / 5 weeks）, synchronous chemotherapy, weekly cisplatin （cisplatin 30 nag/ m2 weekly intravenous infusion） treatment, and another 35 cases of Ibl toⅢ b cervical cancer with radiotherapy only. The efficacy mad adverse re- actions were recorded. Results DDP was administrated at a dose of 30 mg/m2 once a week in the cervical cancer radiotherapy synchronous chemo- therapy, the median cycle of chemotherapy is four weeks, the patient s leukocyte counts of radiotherapy synchronous chemotherapy group were sig- nificantly lower than the radiotherapy group, the incidence of nausea and vomiting was significantly higher in the radiotherapy synchronous chemo- therapy group, the differences were statistically significant （P 〈 0.05 ）. However, in the long-term efficacy, radiotherapy synchronous chemotherapy showed a 3-year disease-free survival rate of 92.7%, 5-year disease-free survival rate of 61.4%, which was 86.8% and 54.4% in the radiotherapy group, the difference was statistically significant （P = 0.038 ）. Conclusion During the radiotherapy synchronous chemotherapy in cervical cancer treatment, cisplatin was dosed at 30 mg/m2 with weekly intravenous infusion, and 4 weeks of chemotherapy treatment exhibited a promising clinical effects.

关 键 词：子宫颈癌 顺铂 放化同步治疗 

分 类 号：R737.3[医药卫生—肿瘤]