喉癌组织中p27蛋白的表达及临床意义  

p27 Protein expression and its significance in human laryngeal carcinoma

作　　者：秦学玲[1] 郭清华[2] 郑虹[1] 郑芸[1] 

机构地区：[1]华西医科大学附属第一医院耳鼻咽喉科,成都610041 [2]大理医学院附属医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉科杂志》2000年第12期533-535,共3页Journal of Clinical Otorhinolaryngology

摘　　要：目的 :探讨 p2 7蛋白在喉癌组织中的表达及临床意义。方法 :以链亲合素 -生物素 L SAB免疫组化方法 ,测定 5 0例喉癌组织中 p2 7蛋白的表达 ,并以 15例声带息肉组织为对照。结果 :p2 7蛋白在喉鳞癌中的表达与声带息肉的表达差异有显著性意义 ;在喉癌临床分期中差异无显著性意义 ,在喉癌病理分级 G1 ～ G2 与 G3之间差异较明显 ,在有无颈淋巴结转移间差异无显著性意义 ,在喉癌术后 3年生存与死亡间差异有显著性意义。 p2 7蛋白表达阴性组和阳性组的生存率曲线 (Kaplan- m eier曲线 )差异有显著性意义。结论 :p2 7蛋白的表达与喉癌恶性程度有关 ,可作为判断喉癌的恶性程度和预后的重要指标。Objective:To determine clinical significance and expression of p27 protein in human laryngeal carcinoma tissue. Method:To measure p27 protein expression in 50 cases laryngeal carcinoma tissue by immunohistochemical LSAB (labelled streptavidin biotin) method, 15 cases vocal cord polyps used as control.Result:There was significant difference between p27 protein expression in laryngeal carcinoma and in vocal cord polyps, among pathological staging of laryngeal carcinoma (G 1 G 2 and G 3), between the survived and the dead laryngeal carcinoma patients 3 years after operation, but no significant difference among clinical staging and between the patients with and without lymph node metastases. There was significant difference between the survival rate curves (Kaplan meier curve) in p27 protein expression positive group and that in p27 protein expression negative group.Conclusion:p27 Protein expression is related to malignant degree of laryngeal carcinoma, so it can be an important marker of identifying the malignancy and prognosis of laryngeal carcinoma.

关 键 词：P27蛋白 喉肿瘤 鳞状细胞癌 恶性程度 预后 

分 类 号：R739.65[医药卫生—肿瘤]