甲状腺功能性腺瘤及弥漫肿大的（131）~I消融作用  

The Ablation Effect of （131）~Ⅰ Therapy on High Functional Thyroid Nodular and Diffuse Goiter

作　　者：王向龙[1] 周新建[2] 赵媛[2] 

机构地区：[1]驻马店市疾病预防控制中心,河南驻马店463000 [2]北京中医药大学东方医院,北京100078

出　　处：《肿瘤学杂志》2013年第12期940-943,共4页Journal of Chinese Oncology

基　　金：北京中医药大学临床自主创新课题(2011jyb22jsy-084)

摘　　要：[目的]评价引起甲状腺功能亢进症自主功能性甲状腺瘤及弥漫肿大131I治疗的消融作用。[方法]182例甲亢患者,于131I治疗前进行甲状腺显像,诊断甲亢病因;131I治疗后6个月再次进行甲状腺显像,观察比较治疗前后131I的消融结果。[结果]182例患者中甲状腺自主性高功能腺瘤18例(9.89%),多结节性甲状腺肿伴甲亢5例(2.75%);弥漫性甲状腺肿大伴甲亢(Graves’病)159例(87.36%)。甲状腺自主性高功能腺瘤18例患者均治愈,有2例出现甲减。Graves’病一次治愈130例(81.8%),其中甲状腺功能正常99例(62.3%),早发甲减31例(19.5%);未愈29例(18.2%)。治疗前和131I消融后6个月甲状腺显像甲状腺质量明显缩小,分别为49.1g和26.9g。[结论]131I对甲状腺瘤及弥漫肿大有显著消融作用。[Purpose] To investigate the effect of131I ablation for high functional thyroid nodular and diffuse goiter.[Methods] A total of 182 patients with hyperthyroidism undergoing thyroidual nuclide imaging pre radioiodine-131 therapy,and divided into 3 types：Graves＇ disease,thyroid toxic adenoma and thyroid toxic multinodular goiter.And the results pre and post 131I ablation were compared.[Results] Of 182 cases,thyroid autonomy high functional adenoma was 18（9.89%） cases;toxic multinodular goiter,5（2.75%） cases;Graves＇ disease,159（87.36%）.All 18cases with thyroid autonomous functioning adenomas were cured,while 2 patients occurred hypothyroidism.One hundred and thirty cases with Graves＇ disease were cured,accounted for81.8%,99 patients（62.3%） had normal thyroid function,31 patients（19.5%） occurred early hypothyroidism,and 29 patients（18.2%） were not cured.Compared with thyroid weight before iodine-131 treatment（49.1g）,it reduced after 6 months iodine-131 treatment（26.9g）.[Conclusions] Radioiodine-131 has significant ablation effect for thyroid adenoma and diffuse goiter.

关 键 词：格雷夫斯病 甲状腺自主性高功能腺瘤 毒性多结节性甲状腺肿 甲状腺显像 碘-131 

分 类 号：R781.63[医药卫生—口腔医学]