乳腺癌（18）~F-FDGPET/CT显像SUV_（max）与Ki67、ER、PR、Her-2的关系  

The Correlation Between FDG Uptake and Expressions of Ki67,ER,PR,Her-2 in Breast Cancer

作　　者：唐明灯[1] 刘道佳[1] 林端瑜[1] 张杰平[1] 李生栩[1] 蔡志华[1] 

机构地区：[1]福建省肿瘤医院,福建福州350014

出　　处：《肿瘤学杂志》2013年第12期944-946,共3页Journal of Chinese Oncology

摘　　要：[目的]探讨18F-FDG PET/CT显像SUV max与免疫组化指标Ki67、ER、PR、Her-2的关系。[方法]选择2011年10月至2012年12月经手术或活检证实为乳腺癌患者46例,在手术或活检前一周内行PET/CT检查,并将肿瘤组织行Ki67、ER、PR、Her-2检测。数据统计采用Pearson直线相关分析和独立分组t检验。[结果 ]SUV max为1.2~13.0,平均为6.630±3.250;Ki67为10%~80%,平均值为43.040%±23.200%,SUV max与Ki67呈正相关（r=0.752,P=0.000）;ER阳性组SUV max为5.700±2.195,阴性组SUV max为7.673±4.438,差异有统计学意义（t=-1.370,P=0.003）;PR阳性组SUVmax为6.285±2.761,PR阴性组SUV max为7.110±4.434,差异无统计学意义（t=-0.549,P=0.099）;Her-2阳性组SUV max为6.706±3.480,Her-2阴性组SUVmax为6.420±4.064,差异无统计学意义（t=0.157,P=0.912）。[结论]SUV max可反映乳腺癌组织中Ki67的表达水平,并有助于确认ER的表达状态,SUV max高的乳腺癌ER表达状态可能为阴性,但SUV max与乳腺癌PR、Her-2的表达状态无关。[Purpose] To evaluate the correlation between SUVmax over tumor foci on 18F-FDG PET/CT scan and biomarkers of Ki67,ER,PR and Her-2.[Methods] Forty-six breast carcinoma patients underwent 18F-FDG PET/CT scan.The tumor specimens were analyzed by immunohistochemical staining for Ki67,ER,PR and Her-2.Pearson linear correlation and independent t-test were applied for statistical analysis.[Results] The mean 18F-FDG SUVmax and Ki67 index were 6.630±3.250（range：1.2~13.0） and 43.040%±23.200%（range：10%~80%）respectively.SUVmax positively correlated with Ki67（r=0.752,P=0.000）.The mean18F-FDG SUVmax of ER（＋） group and ER（-） group were 5.700±2.195 and 7.673±4.438 respectively,with significant difference（P0.05）.The mean18F-FDG SUVmax of PR（＋） group and PR（-） group were 6.285±2.761 and 7.110±4.434 respectively,without significant difference（P0.05）.The mean18F-FDG SUVmax of Her-2（＋）group and Her-2（-） group were 6.706±3.480 and 6.420±4.064 respectively,without significant difference（P0.05）.[Conclusion] 18F-FDG SUVmax may reflect the expression level of Ki67 and may be helpful to confirm expression status of ER where a tumor with a higher 18F-FDG SUVmax usually indicates the tumor with no or less expression of ER.But 18F-FDG SUVmax does not correlate to expression of PR and Her-2 in breast cancer.

关 键 词：乳腺肿瘤 体层摄影术 发射型计算机 体层摄影术 X线计算机 脱氧葡萄糖 

分 类 号：R737.9[医药卫生—肿瘤]