关节腔内注射氨基葡萄糖治疗兔颞下颌关节骨关节炎的组织学研究  

Histological study on the intra-articular injection of glucosamine in the temporomandibular joint osteoarthritis treatment of rabbits

作　　者：阴健[1] 廖爽[1] 张伟华[2] 何嘉[3] 王航[1] 

机构地区：[1]口腔疾病研究国家重点实验室华西口腔医院修复科(四川大学),成都610041 [2]郑州大学第四附属医院科教研科,郑州450000 [3]口腔疾病研究国家重点实验室华西口腔医院颞颌关节科(四川大学),成都610041

出　　处：《国际口腔医学杂志》2014年第1期36-39,共4页International Journal of Stomatology

基　　金：四川省科技厅科技支撑计划基金(2011SZ0157)

摘　　要：目的探讨关节腔内注射氨基葡萄糖治疗兔颞下颌关节(TMJ)骨关节炎(OA)的效果。方法 6只新西兰大白兔采用双侧关节上腔注射Ⅱ型胶原蛋白酶(3 mg,第1天、第4天)的方法建立TMJ OA动物模型。第6周于右侧(实验组)TMJ关节上腔注射氨基葡萄糖溶液0.5 mL(每周1次,注射5周),左侧(对照组)注射等量生理盐水。关节腔注射后11周处死动物,解剖TMJ进行组织学评分。结果所有关节均表现出OA的病理改变,但实验组病损明显较对照组轻。实验组评分显著低于对照组,差异具有统计学意义。结论关节腔内注射氨基葡萄糖能显著缓解兔TMJ OA。Objective This study aims to investigate the effect of glucosamine intra-articular injection in temporomandibular joint（TMJ） osteoarthritis（OA） treatment of rabbits. Methods lntra-articular injection of type Ⅱ collagenase was performed bilaterally in six rabbits to induce OA（3 mg each on Days 1 and 4）. On Week 6, the right joint（experimental group） was injected with glucosamine（once a week for 5 weeks）, and the left joint（control group） was injected with physiological saline. On Week 11, six rabbits were sacrificed, and the TMJs were dissected for histological comparison. Results All joints showed osteoarthritic-like change, but the degree in the experimental group was significantly less severe than that in the control group. Moreover, the scale of the experiment group was significantly less than that of the control group. Conclusion Intra-articular injection of glucosamine can significantly relieve TMJ OA in rabbits.

关 键 词：颞下颌关节 骨关节炎 氨基葡萄糖 治疗 

分 类 号：R782.6[医药卫生—口腔医学]