肺良性转移性平滑肌瘤39例临床特征分析  

Clinical features of 39 patients with pulmonary benign metastasizing leiomyoma

作　　者：罗泽如[1] 冯素玲[2] 高兴林[1] 

机构地区：[1]广东省人民医院(广东省医学科学院)广东省老年医学研究所呼吸科,广州510080 [2]中山大学孙逸仙纪念医院呼吸科,广州510120

出　　处：《国际呼吸杂志》2013年第24期1857-1860,F0003,共5页International Journal of Respiration

摘　　要：目的分析肺良性转移性平滑肌瘤的临床特点，加强临床医师对其的认识。方法对国内报道的总共39例肺良性转移性平滑肌瘤的资料进行整理、分析。结果39例均为女性，平均年龄43．8岁；94．9％有子宫肌瘤手术病史，术后发现肺部转移病灶的时间平均8．3年；呼吸道症状不明显，主要为咳嗽，占28．2％；胸部影像学表现主要为双肺多发结节，占76．9％，其次为单发结节或肿块，占15．4％；病灶直径最大为7cm，结节边界基本比较清晰，未见钙化及强化。雌激素受体阳性率为92．9％，孕激素受体阳性率为96．4％。结论肺良性转移性平滑肌瘤多发生在有子宫平滑肌瘤病史的女性，症状不明显，影像学主要表现为双肺多发结节，大部分病例雌激素受体及孕激素受体表达阳性，手术切除及抗雌激素是主要的治疗方法。Objective To investigate the clinical features of pulmonary benign metastasizing leiomyoma and enhance the consciousness to it. Methods A total of 39 cases of pulmonary benign metastasizing leiomyoma were reported in china, and their data were analyzed. Results 39 cases were female,with mean age of 43.8 years old. 94.9% patients had uterine leiomyoma surgery and pulmonary metastasis were found after surgery with mean time of 8.3 years. Respiratory symptom was not obvious and cough was the main symptom （28.2%）. Multiple pulmonary lesions were found （76.9%） on chest imaging,followed by single nodules or mass （15.4%）. Lesions maximumal diameter was 7 cm. Most lesions were smoothly marginated with well-defined borders, without calcification and aggrandizement in CT. Positive rates of estrogen receptor and progestogen receptor were 92.9% and 96.4% ,respectively. Conclusions Pulmonary benign metastasizing leiomyoma usually occurs in women after uterine leiomyoma surgery,without obvious symptom. Multiple pulmonary lesions are found in chest imaging. The expressions of estrogen receptor and progesterone receptor are positive in most cases, and surgical resection and anti-estrogen are the effective treatment.

关 键 词：继发性肺肿瘤 良性转移性平滑肌瘤 子宫平滑肌瘤 

分 类 号：R737.33[医药卫生—肿瘤]