中西医结合治疗慢性萎缩性胃炎的疗效观察及对炎性细胞因子的影响  

Integrative treatment of chronic atrophic gastritis efficacy and effects on inflammatory cytokines

作　　者：张和逊 郑逢民 

机构地区：[1]浙江省瑞安市中医院中药房,浙江瑞安325200 [2]浙江省瑞安市中医院中医科,浙江瑞安325200

出　　处：《中国现代医生》2014年第1期103-105,共3页China Modern Doctor

基　　金：浙江省中医药科技计划(2013ZB124)

摘　　要：目的探讨中西医结合治疗慢性萎缩性胃炎的疗效观察及对炎性细胞因子的影响。方法选择2010年1月～2012年1月我院住院治疗的慢性萎缩性胃炎患者100例，均经胃镜及病理检查确诊，根据治疗方法不同随机分为两组，观察组（中西医联合治疗）50例，对照组（西医治疗）50例，比较两组CAG患者治疗后的临床疗效；两组CAG患者治疗后的临床表现如胃痛、纳差、乏力、痞满、嗳气、口干、口苦、大便不调的改变情况。两组CAG患者治疗前后胃镜检查示黏膜呈颗粒状、黏膜血管显露、黏膜色泽灰暗、黏膜皱壁变薄方面情况；两组CAG患者治疗前后IL-6、TNF-α水平的变化情况。结果观察组CAG患者的总有效率达94．0％，明显高于对照组，差异有统计学意义（P〈0．05）。观察组CAG患者治疗后的临床表现如胃痛、纳差、乏力、痞满、嗳气、口干、口苦、便溏均较治疗前例数明显减少，且观察组CAG患者上述临床症状均较对照组明显减少（P〈0．05）。观察组CAG患者治疗后在黏膜呈颗粒状、黏膜血管显露、黏膜色泽灰暗、黏膜皱壁变薄方面均较对照组例数明显减少（P〈0．05）。两组CAG患者治疗后IL-6、TNF-α水平均分别较治疗前明显降低（P〈0．01），且观察组CAG患者治疗后IL-6、TNF-α水平较对照组降低更显著（P〈0．05或P〈0．01）。结论中西医结合治疗慢性萎缩性胃炎可以提高疗效，改善患者的临床症状及胃镜表现．抑制炎症因子IL-6、TNF-α的水平。值得推广和应用。Objective To investigate the efficacy on inflammatory cytokines of combination therapy of chronic atrophic gastritis. Methods From January 2010 to January 2012 in our hospital, 100 patients with chronic atrophic gastritis were randomly divided into two groups according to the different treatment methods, the observation group （TCM combination therapy） 50 cases,the control group （western medicine） 50 cases, the clinical efficacy, CAG patients after two clinical manifestations such as stomach pain, anorexia, fatigue, fullness, belching, dry mouth, mouth bitter, not adjusted for changes in bowel condition. CAG two groups before and after treatment endoscopy showed granular mucosa, mucosal vascular revealed, mucosal color gray, thinning of mucosal folds aspects. CAG groups of patients before and after treat- ment IL-6、TNF-α level changes were compared. Results The total effective rate of observation group with CAG was 94.0%, was significantly higher than the control group, the difference was statistically significant （P 〈 0.05）. The clinical manifestations such as stomach pain, anorexia, fatigue, fullness, belching, dry mouth, mouth pain, loose stools precedent of the number of observation group patients CAG significantly reduced than the control group, the difference was statistically significant （P 〈 0.05）. CAG observation group after treatment in granular mucosa, mucosal vascular re- vealed, mucosal color gray, thinning areas mucosal folds than control group patients was significantly decreased （P 〈 0.05）. CAG two groups after treatment IL-6、TNF-α levels were significantly lower than before treatment, respectively （P 〈 0.01）, and the observation group CAG patients after IL-6、TNF-α levels decreased more significantly than the control group （P 〈 0.05 or P 〈 0.01）. Conclusion The combination therapy of chronic atrophic gastritis can enhance the effectiveness and improve the patient＇s clinical symptoms and endoscopic features to consider may be related to inhibi- tion

关 键 词：慢性萎缩性胃炎 益胃汤 胃镜表现 IL-6 TNF-Α 

分 类 号：R573.3[医药卫生—消化系统]