金黄地鼠颊囊鳞癌的^(192)铱放射损伤超微结构研究  

Ultrastructure of Syrian Hamster Buccal Pouch Carcinoma after Irradiation with Ir-192

作　　者：刘建华[1] 陆梅[2] 陈华 

机构地区：[1]浙江大学医学院附属第一医院,浙江杭州310003 [2]浙江大学医学院附属第二医院,浙江杭州310009 [3]武警杭州医院,浙江杭州310004

出　　处：《浙江大学学报（医学版）》2000年第1期16-18,共3页Journal of Zhejiang University(Medical Sciences)

基　　金：浙江省卫生厅科研基金

摘　　要：目的:探讨192铱后装放疗对口腔癌的损伤和选择放疗的合适剂量。方法:以金黄地鼠颊囊鳞癌为模型,经192铱600Gy辐射后取材,并以颊囊粘膜上皮和未经辐射之鳞癌组织作为对照,在电镜下观察。结果:经192铱600Gy辐射后,癌细胞的线粒体变性、坏死,粗面内质网扩张,核仁破碎,染色质颗粒边集,表现为早期坏死的特征。结论:600Gy的单次放射剂量足以引起金黄地鼠口腔鳞癌细胞的不可逆损伤,此剂量可为临床用192铱后装放疗治疗口腔癌作参考。Objective:To study the mechanism of Ir-1 92 afterloading rediotherapy on human oral cancer and to determine adequate dosage of clinical application.Methods:Squamous cell carcinoma (SCC) of syrian hamster buccal pouch was taken as experimental subject,and the cancer model with Ir-1 92 afterloading machine,irradiated.The unirradiated cancer tissue and normal muccosa epithelium of syrian hamster buccal pouch were taken as control,and observed the adove tissues under electron mic-roscope.Results:After irradiation with Ir-1 92 ,cancer cell structure changed irreversibly as follows:mitochondria were degenerated and necrosed,endoplasmic reticulum dilated,nucleolus broken,and chromatin centrifuged.Conclusion:6 0 0 Gy of Ir-1 92 irradiation each time might be eonugh to check buccal pouch carcinoma of Syrian hamster irreversibly,the dose can be used as clinical reference.

关 键 词：超微结构 颊囊鳞癌 放射损伤 铱192 金黄地鼠 

分 类 号：R739.85[医药卫生—肿瘤] R818.74[医药卫生—临床医学]