卵巢恶性上皮性肿瘤中树突状细胞的免疫组织化学研究  

Immunohistochemical study on dendritic cells in epithelial ovarian cancer

作　　者：肖国宏 陈惠祯[2] 张桂清 郑秀玲 

机构地区：[1]广东省广州市第二人民医院,510150 [2]湖北医科大学,武汉430071

出　　处：《广东医学》2001年第2期129-130,共2页Guangdong Medical Journal

摘　　要：目的　探讨树突细胞在卵巢恶性上皮性肿瘤中的浸润情况及其临床意义。方法　用S -10 0蛋白抗体对48例卵巢恶性上皮性肿瘤组织中间质树突细胞进行免疫组化S -P法标记染色 ,并与正常组织及卵巢良性上皮性肿瘤对照。结果　卵巢恶性上皮性肿瘤组织中树突细胞浸润明显增多 (P <0 .0 1) ,树突细胞浸润数量与组织类型 ,分化程度无关 ,而与淋巴细胞浸润呈直线相关 (P <0 .0 1)。树突细胞浸润程度与患者预后呈正相关 (P <0 .0 5 )。结论　树突细胞的浸润可能与肿瘤免疫有关 ,肿瘤组织原位树突细胞计数 。Objective To study the infiltration of dendritic cells(DC) in epithelial ovarian cancer. Methods \ Quantitative assessment of interstitial dendritic cells was performed by S-P immunohistochemical method in specimens of maligmant epithelial ovarian tumor ( n =48),benign epithelial ovarian tumor( n =30),and normal ovarian tissue( n =30). Results\ The number of DC in maligmant epithelial ovarian tumor increased significantly as compared with benign epithelial tumor and normal ovarian tissue( P <0.01).The DC number in maligmant epithelial ovarian tumor was not correlated with histologic types and differentiation grades, but was correlated with lymphocyte infiltration and survival rate. Conclusion\ DC may play a role in the host immune reaction against tumor and the number of DC in situ can serve as a useful indicator in assessing prognosis.

关 键 词：树突状细胞 S-100蛋白 免疫组织化学 卵巢恶性上皮性肿瘤 

分 类 号：R737.31[医药卫生—肿瘤] R730.231[医药卫生—临床医学]