外周血CD3^+CD56^+T细胞在恶性肿瘤患者中的表现及临床意义  

Expression and clinical significance of CD3^+CD56^+ T cell in the peripheral blood on patients with malignant tumor

作　　者：冯伟华[1] 王兰兰[1] 武永康[1] 雷松[2] 刘瑾[1] 

机构地区：[1]华西医科大学附属第一医院临床免疫实验室,四川成都610041 [2]华西医科大学附属第一医院肿瘤生物治疗研究中心,四川成都610041

出　　处：《免疫学杂志》2001年第1期47-49,共3页Immunological Journal

摘　　要：目的了解 CD3+ CD5 6 + T细胞与 CD3- CD5 6 + 、CD3+ CD5 6 - 的关系及其在参与恶性肿瘤患者抗肿瘤免疫中的作用。方法采用流式细胞术对 10 0例恶性肿瘤患者 (5 5例实体瘤患者和 45例非实体瘤患者 )及 46例健康对照组外周血中的 CD3+ CD5 6 +、CD3- CD5 6 +、CD3+ CD5 6 - 3类淋巴细胞进行标记分析。结果在实体瘤和非实体瘤患者组中 :CD3+ CD5 6 + T细胞均有高表达 ,2组患者与健康对照组比较均有显著性差异 (P<0 .0 1)。 CD3+ CD5 6 - T细胞在实体瘤组的表达都显著低于非实体瘤组和健康对照组 ,2组间比较均有显著性差异 (P<0 .0 0 1) ;而 CD3- CD5 6 + NK细胞在 2患者组中的表达与健康对照组比较均无显著性差异 (P>0 .0 5 )。结论 CD3+ CD5 6 + T细胞在恶性肿瘤患者外周血中的高表达较 CD3- CD5 6 + NK细胞更明显 ,并且不受恶性肿瘤细胞类型的影响 ,提示高表达的 CD3+ CD5 6 +ObjectiveTo study the relationship of CD3 +CD56 + between CD3 -CD56 +NK cells and CD3 +CD56 - T cells and anti tumor activity of CD3 +CD56 + T lymphocytes of patients with malignant tumor.MethodsWe analysed CD3 -CD56 +,CD3 +CD56 -,CD3 +CD56 + T lymphocytes in blood samples of 100 patients(from 55 soft tumor patients and 45 non soft tumor patients)and in 46 healthy control by flow cytometry.ResultsHigh expression of CD3 +CD56 + in T cells was found both in soft tumor group and in non soft one,there was significant difference between both the two groups and the control group( P <0 01).The expression of CD3 +CD56 + T cells was much lower in soft tumor group than the non soft tumor group and healthy control( P <0 001),no significant difference was found in the expression of CD3 -CD56 +NK cells among the three groups( P >0 05).ConclusionThe CD3 +CD56 +expression was more abvious in the peripheral blood of patients with malignant tumor than CD3 -CD56 + NK cell.It was not influenced by the type of malignant tumor.It shows that the high expression of CD3 +CD56 + T cells is one of the most important factors that make T lymphocytes to exert anti tumor immunological function.

关 键 词：CD3^+CD56^+ 恶性肿瘤 T细胞 细胞免疫 

分 类 号：R730.3[医药卫生—肿瘤]