甲胎蛋白异质体检测在肝癌诊断中的意义  

Diagnosis effect ofα-fetoprotein heterogeneity in the liver cancer

作　　者：高永庆[1] 徐长青[1] 刘立强[1] 

机构地区：[1]辽宁省铁岭市中心医院检验科,112000

出　　处：《检验医学与临床》2013年第23期3144-3145,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨甲胎蛋白异质体检测在肝癌诊断中的价值。方法选取1 052例甲胎蛋白(AFP)≥20ng/mL的患者,取血清,采用凝集素亲和免疫电泳法检测AFP异质体。结果肝癌患者AFP-L3比值高于良性慢性肝病患者,AFP-L3/AFP>35%时诊断特异度较高。结论 AFP异质体检测在高AFP人群中具有重要的肝癌诊断意义,但还需结合其他手段长期监测。Objective To discuss the utility of α-fetoprotein heterogeneity in the diagnosis of liver cancer. Methods Serum obtained from 1 052 patients with serum α-fetoprotein≥20 ng/mL. Leetin affinity electrophoresis was used to test the contents of AFP heterogeneity . Results The proportion of α-fetoprotein-L3 with liver cancer patients was significantly higher than that in the benign chronic liver disease patients . There were got a high speci- ficity when AFP-L3/AFP〉35%. Conclusion It＇s has a important significance of α- fetoprotein heterogeneity detec- tion. meanwhile, other means should be adopted.

关 键 词：甲胎蛋白 甲胎蛋白异质体 肝癌 

分 类 号：R735.7[医药卫生—肿瘤]