中性粒细胞与淋巴细胞比值预测急性胰腺炎严重程度的意义  

Significance of prediction the severity of acute pancreatitis by neutrophil-to-lymphocyte ratio

作　　者：胡秦妮[1] 张玉琴[2] 邓芝云[1] 林静[1] 肖娜娜[1] 杨志华[1,3] 赵晋[1] 哈小琴[1,3] 

机构地区：[1]中国人民解放军兰州军区兰州总医院检验科,甘肃兰州730050 [2]中国人民解放军兰州军区拱星墩第二干休所,甘肃兰州730030 [3]甘肃省干细胞与基因药物重点实验室,甘肃兰州730050

出　　处：《国际检验医学杂志》2013年第23期3119-3121,共3页International Journal of Laboratory Medicine

基　　金：国家自然科学基金资助项目(81060015)

摘　　要：目的探讨中性粒细胞与淋巴细胞比值(NLR)预测急性胰腺炎严重程度的意义。方法采集60例急性胰腺炎患者的外周血标本,将其分为轻症型急性胰腺炎(MAP)组和重症急性胰腺炎(SAP)组。检测各组患者外周血中WBC,中性粒细胞、淋巴细胞及NLR水平。评估其与急性胰腺炎严重程度之间的关系。结果 SAP组与MAP组患者WBC、中性粒细胞、淋巴细胞及NLR水平比较,差异均具有统计学意义(P<0.05)。60例急性胰腺炎患者WBC及NLR预测SAP的受试者工作特征曲线下面积(AUC)均不低于0.7。NLR较WBC预测SAP的诊断临界(CO)值、敏感性、特异性、AUC具有更大的价值,而中性粒细胞及淋巴细胞在SAP的早期诊断中意义不大。结论 NLR在预测急性胰腺炎的不良预后中优于WBC。Objective To investigate the significance of prediction the severity of acute pancreatitis by neutrophil-to-lymphocyte ratio（NLR）.Methods Peripheral blood specimens of 76 patients with acute pancreatitis were collected and were divided into mild acute pancreatitis（MAP） group and severe acute pancreatitis（SAP） group.WBC,neutrophils,lymphocytes and NLR levels in peripheral blood of patients in each group were detected.Their relationship with severity of acute pancreatitis was evaluated.Results Compared with WBC,neutrophils,lymphocytes and NLR levels of patients between SAP and MAP group,the differences showed statistical significance（P〈0.05）.According to prediction SAP with WBC and NLR,area under the receiver operator characteristic curve（AUC） of 60 patients with acute pancreatitis were not less than 0.7.Diagnostic cut off value,sensitivity,specificity,AUC of NLR showed greater value than those of WBC in SAP prediction while neutrophils and lymphocytes had little significance in early SAP diagnosis.Conclusion NLR is superior to WBC in predicting poor prognosis of acute pancreatitis.

关 键 词：胰腺炎 急性 预后 中性粒细胞 淋巴细胞 中性粒细胞与淋巴细胞比值 

分 类 号：R576[医药卫生—消化系统]