孕中期唐氏综合征的血清学二联与三联产前筛查的比较分析  

Comparative analysis of double and triple prenatal serum screening for Down′s syndrome during the second trimester

作　　者：李剑[1] 骆建云[1] 漆洪波[1] 

机构地区：[1]重庆医科大学附属第一医院妇产科产前诊断中心,重庆400016

出　　处：《国际检验医学杂志》2013年第23期3138-3139,共2页International Journal of Laboratory Medicine

基　　金：国家临床重点专科建设项目经费资助(201101ckZD)

摘　　要：目的比较妊娠中期孕妇血清甲胎蛋白(AFP)、游离β人绒毛膜促性腺激素(fβ-hCG)二联和AFP、fβ-hCG及游离雌三醇(uE3)三联筛查对唐氏综合征(DS)的检出价值。方法采用时间分辨荧光免疫法测定6 094例单胎孕妇血清AFP、fβ-hCG及uE3,应用Risks 2T分析软件,分别采取二联和三联筛查方案评估胎儿DS风险度。分析两种筛查方法的筛查阳性率、检出率和假阳性率。结果二联及三联筛查的阳性率分别为7.89%(481/6 094)和5.35%(326/6 094),差异有统计学意义(P<0.05)。二联筛查DS检出率为71.43%(5/7),假阳性率为7.82%(476/6 089);三联筛查DS检出率为85.71%(6/7),假阳性率为5.26%(320/6 088)。三联筛查DS风险度均高于二联筛查(P<0.05)。结论孕中期血清学三联筛查对DS的检出优于二联筛查。Objective To compare the detection value of double serum screening of alpha-fetoprotein（AFP）and freeβ-human chorionic gonadotrophin（fβ-hCG）and triple serum screening of AFP,fβ-hCG and unconjugated estriol（uE3） for Down syndrome（DS）during the second trimester pregnancy.Methods Serum AFP,fβ-hCG and uE3 of 6 094 singleton pregnant women were de- tected by time-resolved fluorescence immunoassay and analyzed by Risks 2T analysis software.Double and triple screening were em- ployed to evaluate fetal degrees of DS risk.Screening positive rates,detection rates and false positive rates of the two methods were analyzed.Results The positive rates of double and triple screening were 7.89%（481/6 094）and 5.35%（326/6 094）,respectively, with statistically significant（P〈0.05）.The detection rate and false positive rate of double screening for DS were 71.43%（5/7）, 7.82%（476/6 089）,respectively,and those of triple screening were 85.71%（6/7）and 5.26%（320/6 088）,respectively.The risk degree of triple screening for DS was higher than that of double screening（P〈0.05）.Conclusion Triple serum screening for DS is superior to double screening during the second trimester pregnancy.

关 键 词：唐氏综合征 绒毛膜促性腺激素 β亚单位 人 甲胎蛋白 雌三醇 产前筛查 

分 类 号：R714.5[医药卫生—妇产科学]