妊娠中期孕妇血清IL-1与牙周病的关系  

Relationship of Periodontitis and the Serum Interleukin-1( IL-1 ) Levels in Median Pregnancy

作　　者：陈莹[1,2] 汪涌[1,2] 许晓红 

机构地区：[1]合肥市口腔医院 [2]安徽医科大学合肥口腔临床学院牙周科,安徽合肥230001 [3]合肥市妇幼保健医院检验科

出　　处：《口腔医学研究》2013年第12期1138-1140,共3页Journal of Oral Science Research

基　　金：安徽省科技厅年度重点科研项目(编号:11070403047);合肥市第四周期医学重点学科建设计划资助卫科[2013]237号

摘　　要：目的:研究妊娠中期孕妇血清白细胞介素-1(IL-1)与牙周炎的关系。方法:选择60例中期妊娠妇女为研究对象,其中牙周炎30例,健康对照者30例。分别检查菌斑指数(PLI)、探诊深度(PD)、临床附着丧失(CAL)和出血指数(BI);同时抽取空腹静脉血5mL,以ELISA法测定血清IL-1水平。结果:牙周炎组和对照组之间,PLI、PD、CAL、BI和血清IL-1均有统计学差异(P<0.05);IL-1与牙周临床指数PLI、PD、CAL、BI间相关系数为0.692、0.556、0.342、0.683。结论:血清IL-1与PLI、PD、CAL、BI之间呈正相关关系,提示妊娠中期血清IL-1水平与牙周炎存在关联。Objective： To investigate the relationship of periodontitis and the serum Interleukin-1 （IL-1） levels in median pregnancy. Methods： Based on the periodontal health status, 60 women in median pregnancy were enrolled and categorized as periodontitis （PG, n = 30）, and control group （CG, n = 30）. The clinical periodontal measure ments included plaque index（PLI）, probing depth（PD）, clinical attachment loss （CAL）, and bleeding index（BI）. Meanwhile, fasting peripheral blood sample was collected by venipuncture. The serum IL--） level was quantified by ELISA. Results： The serum IL-1 level and each of the clinical parameters in PG group were significantly higher than those in CG group. The IL-1 level had correlation with PLI, PD, CAL and BI（r=0. 692, 0. 556, 0. 342, 0. 683,respectively）. Conclusion： The IL-1 level had positive correlation with PLI, PD, CAL and BI, which sugges ted that the periodontitis were possibly associated with elevated serum IL-1 level in median pregnancy.

关 键 词：牙周炎 妊娠 白细胞介素-1 

分 类 号：R781.4[医药卫生—口腔医学]