阿尔兹海默病与皮质下型血管性痴呆患者脑血管反应性的比较研究  

The comparison of cerebrovascular reactivity between Alzheimer's disease and Subcortical vascular dementia

作　　者：高永哲[1] 章军建[1] 吴光耀[1] 张洪[1] 舒敏[1] 

机构地区：[1]武汉大学中南医院神经内科,430071

出　　处：《卒中与神经疾病》2013年第6期323-326,共4页Stroke and Nervous Diseases

基　　金：国家自然科学基金资助项目(30970962)

摘　　要：目的了解阿尔兹海默病(AD)相对于皮质下型血管性痴呆患者(SVD)脑血管反应性(CVR)的变化特征及规律。方法应用动脉自旋标记核磁共振技术(ASL)首先定量测定静息状态下两组病例局部脑血流量(rCBF),然后分别吸入5%的CO2各1min,再次测定rCBF,并计算其增加率以代表CVR。结果相比SVD组,AD组在双侧额叶皮质有显著性的CVR下降。结论 AD在双侧额叶皮质CVR的下降可能是鉴别于SVD的一个重要临床客观指标。Objective To investe the different patterns of regional cerebrovascular reactivity （CVR）in Alzheimer＇s disease（A D） comparing to Subcortical vascular dementia （SVD）. Methods Regional cerebral blood flow （rCBF） were measured by arterial spin-labeling （ASL） magnetic resonance, separately. CVR was e- valuated by rCBF change in response to 5 % CO2 inhalation for 1 minute. Results The ASL results showed that CVR calculated by rCBF was impaired severely in bilateral frontal cortices in AD compared to SVD. Conclusions The declined of CVR in bilateral frontal cortices may be the specificity feature in AD patients compared to SVD patients.

关 键 词：阿尔兹海默病 皮质下型血管性痴呆 脑血管反应性 动脉自旋标记核磁共振 

分 类 号：R742[医药卫生—神经病学与精神病学] R749.13[医药卫生—临床医学]