血清γ-谷氨酰转肽酶与冠状动脉病变严重程度的相关性  

Correlation of γ-glutamyltransferase with Severity of Coronary Artery Disease

作　　者：毛玉[1] 徐文俊[1] 宋浩明[1] 刘洋[1] 周琳[1] 

机构地区：[1]上海市同济医院心内科,上海市200065

出　　处：《中国动脉硬化杂志》2013年第11期1013-1018,共6页Chinese Journal of Arteriosclerosis

基　　金：上海市卫生局青年科研资助项目(2009Y071);上海市科学技术委员会科研计划项目(11411951400);上海市卫生局科研课题(2010108)

摘　　要：目的探讨血清γ-谷氨酰转肽酶(GGT)与冠状动脉病变严重程度之间的关系,评估血清GGT与急性冠状动脉综合征(ACS)传统危险因素之间的相互作用。方法顺序选取413名ACS行冠状动脉造影患者,采用Gensini积分法评估病变累及血管支数及狭窄程度。分别检测血清GGT、丙氨酸转氨酶(ALT)、高敏C反应蛋白(hs-CRP)、血脂、尿素氮(BUN)、血肌酐(Scr)、尿酸(UA)、脑钠尿肽(BNP)。结果 Gensini积分高分组血清GGT明显升高(P<0.05);多因素回归分析显示,logGGT与冠状动脉病变支数密切相关,且与2型糖尿病、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDLC)、hs-CRP呈正相关(P<0.05),与年龄呈负相关(P<0.05),其中TC对GGT影响最强。进一步研究Gensini积分与血清GGT及冠心病危险因素的关系,显示logGensini与GGT、ALT、年龄、病变血管支数呈显著正相关(P<0.05)。结论血清GGT参与冠状动脉粥样斑块的发生发展,检测GGT对评估冠状动脉病变的严重程度具有临床应用价值。Aim To explore the relationship between serum~/-glutamyl transferase （GGT） levels and coronary complexity, severity and extent. The interaction of serum GGT with the traditional risk factors of acute coronary syndrome （ACS） was evaluated. Methods 413 consecutive patients with ACS who underwent coronary angiography were en- rolled. Baseline serum GGT levels were measured and Gensini score was calculated from the study population. All patients underwent test of GGT, clinical characteristics, blood lipid, brain natriuretic peptide （ BNP）, blood urea nitrogen, serum ereatinine, uric acid, and measuring risk factors. Results Serum GGT levels demonstrated an increase from Low Gensini tertile to high tertile. In multivariate analysis, a significant positive correlation was found between logGGT levels and the different number of diseased coronary vessels, diabetes mellitus, total cholesterol （TC）, triglyceride （TG）, low density lipo- protein cholesterol （LDLC） and high sensitive C-reactive protein （hs-CRP） （P 〈 0. 05）. TC was the strongest influence on logGGT. Further studying the relations between coronary stenosis severity （Gensini score） and serum GGT as well as the traditional risk factors of ACS, the results showed logGensini had a significant positive correlation with serum GGT, age, ALT, smoking, the different number of diseased coronary vessels （P 〈 0. 05 ）. Conclusion Serum GGT involved the development of coronary plaque, serum GGT tested has important clinical values in assessing the severity of coronary artery disease.

关 键 词：急性冠状动脉综合征 y-谷氨酰转肽酶 氧化应激 GENSINI积分 

分 类 号：R5[医药卫生—内科学]